3-Bromo-5-fluoro-4-hydroxybenzoic acid CAS 1781774-76-2
| CAS No. | 1781774-76-2 |
| Molecular Formula | C7H4BrFO3 |
| Molecular Weight | 235.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 235.01 g/mol gives 3-Bromo-5-fluoro-4-hydroxybenzoic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-Bromo-5-fluoro-4-hydroxybenzoic acid (CAS 1781774-76-2), molecular formula C7H4BrFO3 and molecular weight 235.01 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-Bromo-5-fluoro-4-hydroxybenzoic acid (C7H4BrFO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Bromo-5-fluoro-4-hydroxybenzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4BrFO3 |
| Molecular Weight | 235.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F/Br-containing |
Related Bromo Standards
- 2-Bromo-4-fluoro-6-nitroaniline (CAS 10472-88-5)
- 3-Bromo-6-fluoro-2-nitroaniline (CAS 1119454-21-5)
- 5-Bromo-3-fluoro-2-nitroaniline (CAS 1193385-18-0)
- 2-Bromo-3-fluoro-6-nitroaniline, 97% (CAS 1218764-80-7)
- 3-Bromo-4-fluoro-2-hydroxybenzoic acid (CAS 1257535-20-8)
- 3-Bromo-6-fluoro-2-methyl-5-nitropyridine (CAS 1263282-57-0)
- 2-Bromo-3-fluoro-5-nitroaniline (CAS 1309832-49-2)
- 3-Bromo-2-fluoro-5-nitroaniline (CAS 1309833-32-6)
Recommended Standards
- 2-Bromo-3-fluoro-4-hydroxybenzoic acid (CAS 1697589-51-7)
- 5-Bromo-2-fluoro-4-hydroxybenzoic acid (CAS 1781790-71-3)
- 5-Bromo-4-fluoro-2-hydroxybenzoic acid (CAS 1644-71-9)
- 6-Bromo-3-fluoro-2-hydroxybenzoic acid (CAS 1784095-53-9)
- 4-Chloro-2-(furan-2-yl)-5,6-dimethylpyrimidine (CAS 204394-66-1)
- 4-Methoxy-3-(prop-2-yn-1-yl)benzo[d]thiazol-2(3H)-imine hydrobromide (CAS 102126-12-5)
- d-alpha-Tocopheryl Retinoate (CAS 40516-49-2)
- (3aS,6aS)-5-Ethoxycarbonyl-1H-hexahydropyrrolo[3,4-b]pyrrole (CAS 1114985-14-6)
- 8-Bromo-4-methoxy-2-(trifluoromethyl)quinoline (CAS 587886-08-6)
- 2-((2,5-Dimethylphenyl)sulfonyl)ethanol (CAS 688762-92-7)
- 2-Methyl-4-(methylsulfanyl)benzaldehyde (CAS 956612-78-5)
- 2-[4-(5-Methyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H,9H-pyrimido[1,6-a]azepin-2-yl]-N-(4-methylphenyl)acetamide (CAS 1775338-17-4)
- Diethyl 2-(4-chlorobutyl)malonate (CAS 18719-44-3)
- Semaglutide impurity 260 (CAS CATO-C4X-2226260)
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