Ambrisentan (S)-Hydroxy Acid Impurity CAS 178306-52-0
| CAS No. | 178306-52-0 |
| Molecular Formula | C16H16O4 |
| Molecular Weight | 272.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Ambrisentan (S)-Hydroxy Acid Impurity (CAS 178306-52-0, C16H16O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Ambrisentan (S)-Hydroxy Acid Impurity (C16H16O4) contains a flavonoid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 272.30 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Ambrisentan (S)-Hydroxy Acid Impurity under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H16O4 |
| Molecular Weight | 272.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
Related Ambrisentan Standards
- Ambrisentan Impurity 5 (CAS 178306-51-9)
- Ambrisentan Impurity 8 (CAS CATO-C4X-12468)
- Ambrisentan (R)-Hydroxy Acid Impurity (CAS 178306-49-5)
- Ambrisentan Hydroxyester Impurity (CAS 177036-78-1)
- Ambrisentan Impurity 1 (CAS 178306-47-3)
- Ambrisentan Impurity 7 (CAS CATO-C4X-12467)
- Ambrisentan Impurity N1 (CAS 76527-25-8)
- Ambrisentan Impurity 2 (CAS 1639429-81-4)
Recommended Standards
- H-Glu(αNA)-OH (CAS 28401-75-4)
- 4-Hydroxyphenethylanisate (CAS 87932-34-1)
- H-Glu(βNA)-OH (CAS 14525-44-1)
- Deoxyshikonin (CAS 43043-74-9)
- Clonazepam Impurity 4 (CAS 52130-87-7)
- Apixaban Impurity 135 (CAS CATO-C4X-1088135)
- Betamethasone EP Impurity C (CAS 13504-15-9)
- 1-(3,5-Dichlorobenzyl)pyrrolidine-3-carboxylic acid (CAS 1491876-41-5)
- N2-(2-Chloro-5-(trifluoromethyl)phenyl)-1,3,5-triazine-2,4-diamine (CAS 175204-34-9)
- (1R)-1-((4R,5R,6S)-5-hydroxy-6-(hydroxymethyl)-2-phenyl-1,3-dioxan-4-yl)ethane-1,2-diol (CAS 61340-09-8)
- Cyclobutyl(2-methoxy-1H-imidazol-5-yl)methanone (CAS 959262-56-7)
- 5-(Aminomethyl)-4-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (CAS 1554472-58-0)
- 2-((4-Bromobenzyl)thio)-3-(4-methoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (CAS 477332-86-8)
- Semaglutide impurity 331 (CAS CATO-C4X-2226231)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com