Ambrisentan Impurity 5 CAS 178306-51-9
| CAS No. | 178306-51-9 |
| Molecular Formula | C16H16O4 |
| Molecular Weight | 272.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ambrisentan Impurity 5 is closely related to a flavonoid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Ambrisentan Impurity 5 (CAS 178306-51-9) is a certified pharmaceutical impurity reference standard with the molecular formula C16H16O4 and a molecular weight of 272.30 g/mol.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, Ambrisentan Impurity 5 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 272.30 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ambrisentan Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H16O4 |
| Molecular Weight | 272.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
Related Ambrisentan Standards
- Ambrisentan Impurity 8 (CAS CATO-C4X-12468)
- Ambrisentan (R)-Hydroxy Acid Impurity (CAS 178306-49-5)
- Ambrisentan (S)-Hydroxy Acid Impurity (CAS 178306-52-0)
- Ambrisentan Hydroxyester Impurity (CAS 177036-78-1)
- Ambrisentan Impurity 1 (CAS 178306-47-3)
- Ambrisentan Impurity 7 (CAS CATO-C4X-12467)
- Ambrisentan Impurity N1 (CAS 76527-25-8)
- Ambrisentan Impurity 2 (CAS 1639429-81-4)
Recommended Standards
- Agomelatine Impurity 53 (CAS CATO-C4X-110853)
- Ceritinib Impurity 51 (CAS CATO-C4X-104851)
- Propranolol Impurity 10 (CAS 27610-48-6)
- Ceritinib Impurity 46 (CAS CATO-C4X-104846)
- Cenobamate Impurity 38 (CAS 2973351-59-4)
- Empagliflozin impurity 185 (CAS CATO-C4X-1065185)
- Artemisinin Impurity 18 (CAS CATO-C4X-201218)
- 2-Bromo-4,5-difluorobenzonitrile (CAS 64695-82-5)
- Arbidol-d6 Hydrochloride (CAS CATO-C4X-11291)
- (2E)-2-Cyano-3-(dimethylamino)-N-(2-fluoro-4-hydroxyphenyl)prop-2-enamide (CAS 320424-57-5)
- 2-Amino-N-methylpentanamide (CAS 879553-73-8)
- 4-(5-Methoxy-2-phenylpyrimidin-4-yl)-2,6-dimethylmorpholine (CAS 477863-83-5)
- N,N-Bis(3,5-dimethylphenyl)propanediamide (CAS 1900164-74-0)
- Semaglutide impurity 96 (CAS CATO-C4X-222696)
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