Loxoprofen Impurity 153 CAS 1784924-28-2

Purity ≥95%In StockPharmacopoeial Impurity Standards
CAS No.1784924-28-2
Molecular FormulaC10H12O3
Molecular Weight180.20 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Loxoprofen Impurity 153 CAS 1784924-28-2 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 180.20 g/mol gives Loxoprofen Impurity 153 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Loxoprofen Impurity 153 (CAS 1784924-28-2), a pharmacopoeial impurity reference standard (molecular formula C10H12O3, MW 180.20 g/mol) used for the identification and quantification of trace impurities in APIs.

The molecular framework of Loxoprofen Impurity 153 (C10H12O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC10H12O3
Molecular Weight180.20 g/mol
AppearanceOff-white to pale yellow crystalline powder
Purity≥95%
StorageStore at 2-8°C, keep sealed and dry
Solubility (reference)Soluble in methanol, ethanol, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening
Degree of Unsaturation (DBE)5.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1994

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