Nintedanib Impurity 160 CAS 7207-35-4
| CAS No. | 7207-35-4 |
| Molecular Formula | C9H12N2O2 |
| Molecular Weight | 180.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Nintedanib Impurity 160 (CAS 7207-35-4, C9H12N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C9H12N2O2, Nintedanib Impurity 160 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 180.20 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Nintedanib Impurity 160 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H12N2O2 |
| Molecular Weight | 180.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Nitrogen Atoms | 2 |
Related Nintedanib Standards
- Nintedanib Impurity 38 (CAS 58378-33-9)
- Nintedanib Impurity 42 (CAS 2186-92-7)
- Nintedanib Impurity 43 (CAS 59276-28-7)
- Nintedanib Impurity 66 (CAS 707-07-3)
- Nintedanib Impurity 34 (CAS 334952-09-9)
- Nintedanib Impurity 184 (CAS 873376-89-7)
- Nintedanib Impurity 67 (CAS 40872-87-5)
- Nintedanib Impurity 39 (CAS 3395-81-1)
Recommended Standards
- Desvenlafaxine Impurity 4 (CAS CATO-C4X-16104)
- Esmolol Impurity 17 (CAS 5597-50-2)
- Loxoprofen Impurity 22 (CAS 88416-60-8)
- Esmolol Impurity 40 (CAS 61389-68-2)
- Fexofenadine Impurity 10 (CAS CATO-C4X-179410)
- Ambroxol Impurity 89 (CAS CATO-C4X-108589)
- Quinapril impurity 3 (CAS CATO-C4X-17413)
- Methyl 3',5-dimethyl-[3,5'-biisoxazole]-4'-carboxylate (CAS 175277-12-0)
- 5-(Aminomethyl)-2-fluorobenzenesulfonamide hydrochloride (CAS 1955558-13-0)
- 2-(3-Chlorophenyl)acetimidamide hydrochloride (CAS 6487-96-3)
- 6-(8-Aza-bicyclo[3.2.1]oct-3-ylmethyl)-nicotinic acid hydrochloride (CAS 1361116-65-5)
- 1-(2-Bromoethyl)pyrrolidine (CAS 54035-94-8)
- 3-(Bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-1-methyl-1h-pyrazol-5-amine (CAS 1516211-60-1)
- Insulin Degludec Impurity 8 (CAS CATO-C4X-21578)
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