2-Bromo-4'-chloro-1,1'-biphenyl CAS 179526-95-5
| CAS No. | 179526-95-5 |
| Molecular Formula | C12H8BrCl |
| Molecular Weight | 267.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-Bromo-4'-chloro-1,1'-biphenyl (CAS 179526-95-5) is a high-purity analytical reference standard with the molecular formula C12H8BrCl and a molecular weight of 267.55 g/mol.
The molecular framework of 2-Bromo-4'-chloro-1,1'-biphenyl (C12H8BrCl) is characterized by chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C12H8BrCl |
| Molecular Weight | 267.55 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Halogen Content | Cl/Br-containing |
Related Bromo Standards
- 2-Bromo-2'-chloro-1,1'-biphenyl (CAS 107208-70-8)
- 3-Bromo-5-chloro-1,1'-biphenyl (CAS 126866-35-1)
- 2-Bromo-3'-chloro-1,1'-biphenyl (CAS 154407-17-7)
- 3-Bromo-4'-chloro-1,1'-biphenyl (CAS 164334-69-4)
- 2-Bromo-4-chloro-1,1'-biphenyl (CAS 1805001-22-2)
- 2-Bromo-5-chloro-1,1'-biphenyl (CAS 1936711-65-7)
- 3-Bromo-3'-chloro-1,1'-biphenyl (CAS 844856-42-4)
- 4'-Bromo-2-chloro-1,1'-biphenyl (CAS 39802-88-5)
Recommended Standards
- Nintedanib impurity 181 (CAS CATO-C4X-1814181)
- 4'-Bromo-3-chloro-1,1'-biphenyl (CAS 91354-09-5)
- 2,2,2-Trichloro-1-phenylethyl acetate (CAS 90-17-5)
- 4-Bromo-3-chloro-1,1'-biphenyl (CAS 91354-08-4)
- Diethyl 2-((p-tolylamino)methylene)malonate (CAS 19056-84-9)
- 1-[2-chloro-4-(1H-1,2,4-triazol-1-yl)phenyl]ethan-1-ol (CAS 1343597-11-4)
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- 4-Chloro-6-methyl-1H-indole (CAS 885521-78-8)
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- Tau Peptide (244-274) (Repeat 1 Domain) trifluoroacetate salt (CAS 330456-24-1)
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