Nintedanib impurity 181 CAS CATO-C4X-1814181
| CAS No. | CATO-C4X-1814181 |
| Molecular Formula | C9H9Cl3N2O |
| Molecular Weight | 267.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Nintedanib impurity 181 (CAS CATO-C4X-1814181), a pharmacopoeial impurity reference standard (molecular formula C9H9Cl3N2O, MW 267.54 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C9H9Cl3N2O, Nintedanib impurity 181 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 267.54 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C9H9Cl3N2O |
| Molecular Weight | 267.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Nintedanib Standards
- Nintedanib Impurity 15 (CAS 1160293-25-3)
- Nintedanib Impurity 40 (CAS 78466-25-8)
- Nintedanib Impurity 22 (CAS 262368-30-9)
- Nintedanib Impurity 61 (CAS 2117628-65-4)
- Nintedanib Impurity 65 (CAS 757218-01-2)
- Nintedanib Impurity 95 (CAS 16320-52-8)
- Nintedanib Impurity 92 (CAS CATO-C4X-181492)
- Nintedanib Impurity 84 (CAS 2770008-35-8)
Recommended Standards
- 2,2,2-Trichloro-1-phenylethyl acetate (CAS 90-17-5)
- 2-Bromo-2'-chloro-1,1'-biphenyl (CAS 107208-70-8)
- 2-(2,4-Dichlorophenoxy)butanoyl chloride (CAS 854874-29-6)
- 3-Bromo-5-chloro-1,1'-biphenyl (CAS 126866-35-1)
- Tadalafil Impurity 141 (CAS 477970-21-1)
- Orforglipron impurity 121 (CAS 2212021-39-9)
- Drotaverine Impurity 27 (CAS CATO-C4X-243527)
- Resveratrol-4-acetate (CAS 411233-11-9)
- (9-Isopropyl-9-azabicyclo[3.3.1]nonan-3-yl)methanamine (CAS 1208613-50-6)
- 6-(4-Methoxyphenoxy)hexan-1-ol (CAS 122004-89-1)
- Somatostatin Impurity 22 (CAS CATO-C4X-235022)
- Ethyl 1-methyl-3-oxopiperidine-4-carboxylate hydrochloride (CAS 58020-12-5)
- 2-Fluoro-4,5-dimethoxybenzoic acid (CAS 79474-35-4)
- Neuropeptide Y (18-36) (CAS 114495-97-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com