Gefitinib Impurity 40 CAS 179688-53-0
| CAS No. | 179688-53-0 |
| Molecular Formula | C11H10N2O4 |
| Molecular Weight | 234.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Gefitinib Impurity 40 (CAS 179688-53-0) is a certified pharmaceutical impurity reference standard with the molecular formula C11H10N2O4 and a molecular weight of 234.21 g/mol.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Gefitinib Impurity 40 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 234.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H10N2O4 |
| Molecular Weight | 234.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Nitrogen Atoms | 2 |
Related Gefitinib Standards
- Gefitinib Impurity 25 (CAS 385784-68-9)
- Gefitinib Impurity 79 (CAS CATO-C4X-111779)
- Gefitinib Impurity 86 (CAS CATO-C4X-111786)
- Gefitinib Impurity 78 (CAS CATO-C4X-111778)
- Gefitinib Impurity 73 (CAS CATO-C4X-111773)
- Gefitinib Impurity 88 (CAS CATO-C4X-111788)
- Gefitinib Impurity 80 (CAS CATO-C4X-111780)
- Gefitinib Impurity 91 (CAS CATO-C4X-111791)
Recommended Standards
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- Gadobutrol Impurity 7 (CAS CATO-C4X-21207)
- Tranilast impurity 7 (CAS 88909-07-3)
- Baricitinib Impurity 2 (CAS 2964606-44-6)
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