Gefitinib Impurity 88 CAS CATO-C4X-111788
| CAS No. | CATO-C4X-111788 |
| Molecular Formula | C11H10ClNO2 |
| Molecular Weight | 223.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Gefitinib Impurity 88 (CAS CATO-C4X-111788, C11H10ClNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Gefitinib Impurity 88 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 223.66 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Gefitinib Impurity 88 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H10ClNO2 |
| Molecular Weight | 223.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Gefitinib Standards
- Gefitinib Impurity 73 (CAS CATO-C4X-111773)
- Gefitinib Impurity 78 (CAS CATO-C4X-111778)
- Gefitinib Impurity 80 (CAS CATO-C4X-111780)
- Gefitinib Impurity 91 (CAS CATO-C4X-111791)
- Gefitinib Impurity 79 (CAS CATO-C4X-111779)
- Gefitinib Impurity 25 (CAS 385784-68-9)
- Gefitinib Impurity 40 (CAS 179688-53-0)
- Gefitinib Impurity 86 (CAS CATO-C4X-111786)
Recommended Standards
- Baclofen impurity 23 (CAS 84803-46-3)
- Peridine Impurity 7 (CAS 99983-71-8)
- 2306AF 5-Chloro-2-(2-furylmethoxy)aniline 893751-18-3 C11H10ClNO2 (CAS 893751-18-3)
- Capivasertib Impurity 23 (CAS CATO-C4X-331223)
- Lefamulinum Impurity (CAS CATO-C4X-304728)
- Cholic Aicd Impurity 17 (CAS 2304-91-8)
- Fosfomycin Impurity 59 (CAS 25460-63-3)
- Pentoxyverine Impurity 5 (CAS CATO-C4X-22705)
- 7-(Benzyloxy)-[1,2,4]triazolo[4,3-a]pyridine-8-carboxylic acid (CAS 1262191-85-4)
- N-(2-{[2,5-bis(2,2,2-trifluoroethoxy)phenyl]formamido}ethyl)-2-chloroacetamide (CAS 338404-61-8)
- (2-Chloro-6-fluorophenyl)(cyclopentyl)methanol (CAS 1225687-12-6)
- 1-(Azetidin-3-yl)azetidin-3-ol (CAS 1257293-85-8)
- 2-Undecanol (CAS 1653-30-1)
- [D-His1]-Semaglutide (CAS CATO-C4X-2226127)
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