Pramipexole EP Impurity B Dihydrochloride CAS 1802051-36-0
| CAS No. | 1802051-36-0 |
| Molecular Formula | C13H23N3S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Pramipexole EP Impurity B Dihydrochloride is closely related to a nitrile group, sulfur-containing functionality, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Pramipexole EP Impurity B Dihydrochloride (CAS 1802051-36-0, C13H23N3SHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Pramipexole EP Impurity B Dihydrochloride (C13H23N3SHCl) contains a nitrile group, sulfur-containing functionality, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H23N3S 2*HCl |
| Molecular Weight | 289.87 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Pramipexole Standards
- Pramipexole Impurity 44 (CAS 1001648-65-2)
- Pramipexole USP Related Compound G (CAS 1001648-71-0)
- Pramipexole Impurity 66 (CAS 1001648-73-2)
- Pramipexole Impurity 34 (CAS 1001648-74-3)
- Pramipexole Impurity 43 (CAS 1001648-75-4)
- Pramipexole Impurity 46 (CAS 104617-49-4)
- Pramipexole Impurity 41 (CAS 104617-50-7)
- Pramipexole Impurity 17 (CAS 104617-51-8)
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