2-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane CAS 1802432-22-9
| CAS No. | 1802432-22-9 |
| Molecular Formula | C13H15BClF3O2 |
| Molecular Weight | 306.52 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1802432-22-9), molecular formula C13H15BClF3O2 and molecular weight 306.52 g/mol, is a CATO reference standard with documented purity and traceability.
2-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (C13H15BClF3O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 2-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H15BClF3O2 |
| Molecular Weight | 306.52 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-Chloro-5-(trifluoromethyl)phenylboronic acid pinacol ester (CAS 1146214-95-0)
- 2-[4-Chloro-2-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1165935-85-2)
- 2-(3-Chloro-4-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1165935-97-6)
- 2-[2-chloro-4-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1165935-98-7)
- 2-Chloro-6-(trifluoromethyl)phenylboronic acid pinacol ester (CAS 1451391-09-5)
- 2-(4-Chloro-3-(difluoromethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1544563-33-8)
- 2-Chloro-3-(trifluoromethyl)phenylboronic acid pinacol ester (CAS 1689550-75-1)
- 2-(3-Chloro-2-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2246545-93-5)
Recommended Standards
- (2Z)-3-Methyl-4-(benzyloxy)-2-buten-1-ol tert-Butyldimethylsilyl Ether (CAS 1798394-47-4)
- 2-(4-Chloro-3-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 445303-09-3)
- 5-Chloro-2-(trifluoromethyl)phenylboronic acid pinacol ester (CAS 2121512-57-8)
- 5-Acetyl-2-(2,4,6-trichlorophenyl)-1H-1,2,4-triazol-3(2H)-one (CAS 1000572-21-3)
- Ethyl (4-chlorophenyl)alaninate (CAS 83442-72-2)
- 1-(2,5-Difluorobenzenesulfonyl)piperidine-4-carboxylic acid (CAS 847759-02-8)
- (2-Methyl-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)boronic acid (CAS 1704095-84-0)
- 4-(3,4-Dimethoxybenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(3-nitrophenyl)-1H-pyrrol-2(5H)-one (CAS 615276-06-7)
- 5-Amino-1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-pyrazole-4-carbonitrile (CAS 94038-76-3)
- Ethyl 2-chloro-4-methylpyrrolo[1,2-a]pyrimidine-8-carboxylate (CAS 1919049-54-9)
- tert-Butyl ((5-chloro-4-oxo-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydrophthalazin-1-yl)methyl)carbamate (CAS 2836224-64-5)
- 3-Bromo-N-(2-chlorophenyl)benzenesulfonamide (CAS 848913-61-1)
- Cyclohexyl(pyridin-2-yl)methanone (CAS 6602-64-8)
- Neuropeptide Y (2-36) (human, rat) trifluoroacetate salt (CAS 123139-39-9)
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