4-(Fluoromethyl)-6-hydroxy-3-(trifluoromethoxy)picolinaldehyde CAS 1804795-25-2
| CAS No. | 1804795-25-2 |
| Molecular Formula | C8H5F4NO3 |
| Molecular Weight | 239.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(Fluoromethyl)-6-hydroxy-3-(trifluoromethoxy)picolinaldehyde (CAS 1804795-25-2), molecular formula C8H5F4NO3 and molecular weight 239.12 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(Fluoromethyl)-6-hydroxy-3-(trifluoromethoxy)picolinaldehyde (C8H5F4NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-(Fluoromethyl)-6-hydroxy-3-(trifluoromethoxy)picolinaldehyde under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H5F4NO3 |
| Molecular Weight | 239.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoromethyl Standards
- 4-(Fluoromethyl)-5-(hydroxymethyl)-6-(trifluoromethoxy)pyridin-3-ol (CAS 1806731-44-1)
- 2-(Fluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine (CAS 1220696-61-6)
- 6-(Fluoromethyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (CAS 667420-78-2)
- 2-[4-(fluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1234319-13-1)
- 2-(3-(Fluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2097735-73-2)
- 1-(fluoromethyl)-3-iodobenzene (CAS 456-45-1)
- 2-(Fluoromethyl)-8-methoxyquinoline-6-carboxylic acid (CAS 2721374-93-0)
- 3-(Fluoromethyl)-8-methoxyquinoline-6-carboxylic acid (CAS 2721374-98-5)
Recommended Standards
- 2,4-Bis(trifluoromethyl)benzonitrile (CAS 177952-38-4)
- 2-Amino-5-fluoro-4-(trifluoromethoxy)benzoic acid (CAS 1805276-92-9)
- 3-Chloro-2,5-dimethylbenzenesulfonyl chloride (CAS 166964-40-5)
- 4-Fluoro-1-nitro-2-(2,2,2-trifluoroethoxy)benzene (CAS 186386-91-4)
- Propan-2-yl 2-Sulfanylacetate (CAS 7383-61-1)
- 4-[(Difluoromethoxy)methyl]-3-fluorobenzenemethanamine (CAS 2768153-37-1)
- 2-(Thiophen-2-yl)-5-(p-tolyl)-1,3,4-oxadiazole (CAS 110380-38-6)
- Ethyl 2-(2-chlorophenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate (CAS 1332506-36-1)
- Ethyl 3-{[(pyridin-2-yl)methyl]amino}propanoate (CAS 131436-66-3)
- 5-(5-Methylfuran-2-yl)-1H-pyrazole (CAS 1019010-26-4)
- N-(3-hydroxy-5-methylpyridin-2-yl)pivalamide (CAS 1203499-11-9)
- 3-Amino-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one hydrochloride (CAS 2137936-74-2)
- 2-Iodo-5-trifluoromethyl-pyridine (CAS 100366-75-4)
- a-Bag Cell Peptide (1-8) (CAS 87549-53-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com