Apalutamide Impurity 53 CAS 1805120-01-7
| CAS No. | 1805120-01-7 |
| Molecular Formula | C7H2F3N3O2 |
| Molecular Weight | 217.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C7H2F3N3O2, Apalutamide Impurity 53 contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 217.10 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Apalutamide Impurity 53 (CAS 1805120-01-7) is a certified pharmaceutical impurity reference standard with the molecular formula C7H2F3N3O2 and a molecular weight of 217.10 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H2F3N3O2 |
| Molecular Weight | 217.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Apalutamide Standards
- Apalutamide Impurity 52 (CAS 1803821-36-4)
- Apalutamide Impurity 73 (CAS CATO-C4X-274973)
- Apalutamide Impurity 61 (CAS 1513077-71-8)
- Apalutamide Impurity 117 (CAS CATO-C4X-2749117)
- Apalutamide Impurity 60 (CAS CATO-C4X-274960)
- Apalutamide Impurity 106 (CAS CATO-C4X-2749106)
- Apalutamide Impurity 44 (CAS 1121056-94-7)
- Apalutamide Impurity 64 (CAS 1211542-14-1)
Recommended Standards
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- 2-Aminopyrrolo[3,4-d]imidazol-4(1H)-one (CAS 850474-61-2)
- (3S)-5-methyl-3-({[(3RS,4RS)-4-methylpyrrolidin-3-yl]formamido}methyl)hexanoic acid (CAS 1909293-59-9)
- 1-Methyl-3-(4-morpholinophenyl)-1h-pyrazole-5-carboxylic acid (CAS 1177316-62-9)
- 4-(2-Methoxyethoxy)aniline (CAS 33311-29-4)
- Peptide 46 (H-4054.0500) (CAS 192122-40-0)
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