4-(Difluoromethyl)-6-fluoro-5-hydroxypicolinoyl chloride CAS 1805191-65-4

Purity 97%+In StockPharmaceutical Standards
CAS No.1805191-65-4
Molecular FormulaC7H3ClF3NO2
Molecular Weight225.55 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

4-(Difluoromethyl)-6-fluoro-5-hydroxypicolinoyl chloride CAS 1805191-65-4 chemical structure

Description

The occurrence of 4-(Difluoromethyl)-6-fluoro-5-hydroxypicolinoyl chloride is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

4-(Difluoromethyl)-6-fluoro-5-hydroxypicolinoyl chloride (CAS 1805191-65-4), molecular formula C7H3ClF3NO2 and molecular weight 225.55 g/mol, is a CATO reference standard with documented purity and traceability.

4-(Difluoromethyl)-6-fluoro-5-hydroxypicolinoyl chloride (C7H3ClF3NO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 4-(Difluoromethyl)-6-fluoro-5-hydroxypicolinoyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC7H3ClF3NO2
Molecular Weight225.55 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)5.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1995
Halogen ContentF/Cl-containing
Nitrogen Atoms1

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