2-(Difluoromethyl)-4-(trifluoromethyl)pyridine-5-carbonyl chloride CAS 1805232-93-2
| CAS No. | 1805232-93-2 |
| Molecular Formula | C8H3ClF5NO |
| Molecular Weight | 259.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(Difluoromethyl)-4-(trifluoromethyl)pyridine-5-carbonyl chloride (C8H3ClF5NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
2-(Difluoromethyl)-4-(trifluoromethyl)pyridine-5-carbonyl chloride (CAS 1805232-93-2), molecular formula C8H3ClF5NO and molecular weight 259.56 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-(Difluoromethyl)-4-(trifluoromethyl)pyridine-5-carbonyl chloride under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H3ClF5NO |
| Molecular Weight | 259.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethyl Standards
- 2-(Difluoromethyl)-3-(trifluoromethyl)pyridine-4-carbonyl chloride (CAS 1804446-63-6)
- 2-(Difluoromethyl)-6-(trifluoromethyl)pyridine-4-carbonyl chloride (CAS 1804693-63-7)
- 4-(Difluoromethyl)-5-(trifluoromethyl)picolinoyl chloride (CAS 1804693-85-3)
- 4-(Difluoromethyl)-3-(trifluoromethyl)picolinoyl chloride (CAS 1805009-71-5)
- 4-(Difluoromethyl)-6-(trifluoromethyl)nicotinoyl chloride (CAS 1805233-51-5)
- 2-(Difluoromethyl)-6-(trifluoromethyl)pyridine-3-carbonyl chloride (CAS 1805951-54-5)
- 4-(Difluoromethyl)-2-(trifluoromethyl)nicotinoyl chloride (CAS 1805952-00-4)
- 2-(Difluoromethyl)-5-(trifluoromethyl)pyridine-4-carbonyl chloride (CAS 1806809-70-0)
Recommended Standards
- 2-Chloro-5-(difluoromethyl)-3-(trifluoromethyl)isonicotinaldehyde (CAS 1805082-14-7)
- 6-Chloro-3-(difluoromethyl)-5-(trifluoromethyl)picolinaldehyde (CAS 1805369-27-0)
- 2-Chloro-6-(difluoromethyl)-4-(trifluoromethyl)nicotinaldehyde (CAS 1805369-36-1)
- 4-Chloro-2-(difluoromethyl)-5-(trifluoromethyl)nicotinaldehyde (CAS 1805369-60-1)
- Trichlorotetradecylsilane, 97% (CAS 18402-22-7)
- 8,14-Dihydro-14-methyl-11-(trifluoromethyl)-indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one (CAS 747-91-1)
- Methyl 6-amino-4-methoxyquinoline-2-carboxylate (CAS 169831-76-9)
- 3-((3,3-Dimethylbutan-2-yl)amino)thietane 1,1-dioxide (CAS 1864724-93-5)
- 2-Methyl-3-propylthiophene (CAS 147871-74-7)
- Benzyl (S)-2-(Cyanomethyl)piperazine-1-carboxylate (CAS 2158302-01-1)
- 7-Chloro-5-phenyl-2-(p-tolyl)oxazolo[4,5-d]pyrimidine (CAS 1225162-95-7)
- 4-METHYL VALERYL PIPERIDINE THIOAMIDE (CAS 289677-13-0)
- Ethyl 5-(pyridin-4-yl)oxazole-2-carboxylate (CAS 857334-90-8)
- Exenatide Acetate (CAS 141732-76-5)
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