4-(Chloromethyl)-3-(difluoromethyl)-5-fluoropyridin-2-ol CAS 1805505-67-2
| CAS No. | 1805505-67-2 |
| Molecular Formula | C7H5ClF3NO |
| Molecular Weight | 211.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(Chloromethyl)-3-(difluoromethyl)-5-fluoropyridin-2-ol is closely related to an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-(Chloromethyl)-3-(difluoromethyl)-5-fluoropyridin-2-ol (CAS 1805505-67-2), a certified reference material (molecular formula C7H5ClF3NO, MW 211.57 g/mol) for analytical method development and quality control.
4-(Chloromethyl)-3-(difluoromethyl)-5-fluoropyridin-2-ol (C7H5ClF3NO) contains an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5ClF3NO |
| Molecular Weight | 211.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloromethyl Standards
- 2-(Chloromethyl)-5-(trifluoromethoxy)pyridine (CAS 1060814-93-8)
- 3-(Chloromethyl)-5-(trifluoromethoxy)pyridine (CAS 1060815-05-5)
- 3-Chloromethyl-2-hydroxy-5-(trifluoromethyl)pyridine (CAS 1227562-08-4)
- 4-Chloromethyl-3-hydroxy-2-(trifluoromethyl)pyridine (CAS 1227562-18-6)
- 4-Chloromethyl-2-hydroxy-6-(trifluoromethyl)pyridine (CAS 1227562-24-4)
- 3-Chloromethyl-6-hydroxy-2-(trifluoromethyl)pyridine (CAS 1227564-73-9)
- 4-Chloromethyl-2-hydroxy-3-(trifluoromethyl)pyridine (CAS 1227565-46-9)
- 3-Chloromethyl-2-hydroxy-4-(trifluoromethyl)pyridine (CAS 1227581-23-8)
Recommended Standards
- 4-Chloro-6-(difluoromethyl)-3-fluoro-2-methoxypyridine (CAS 1805390-66-2)
- (6-Chloro-4-(difluoromethyl)-5-fluoropyridin-3-yl)methanol (CAS 1805980-00-0)
- (2-Chloro-6-(difluoromethyl)-5-fluoropyridin-3-yl)methanol (CAS 1805385-19-6)
- (2-Chloro-5-(difluoromethyl)-3-fluoropyridin-4-yl)methanol (CAS 1805980-07-7)
- 3-Hydrazinylpyrrolidine dihydrochloride (CAS 1305282-81-8)
- 4-(4-(4-Ethylphenyl)-5-mercapto-4H-1,2,4-triazol-3-yl)phenol (CAS 917747-23-0)
- 1-(2-Isopropylpyridin-3-yl)ethanone (CAS 1624262-09-4)
- 2-Ethyl-1H-indazol-3(2H)-one (CAS 89438-53-9)
- (1,3,3-Trimethylbicyclo[2.2.1]heptan-2-yl)methanamine (CAS 1212206-83-1)
- Carfilzomib Impurity 55 (CAS 2177287-70-4)
- 2-((1-(2-Amino-2-oxoethyl)-5-(hydroxymethyl)-1H-imidazol-2-yl)thio)-N-(2-chlorobenzyl)acetamide (CAS 921822-04-0)
- (S)-tert-Butyl 2-(fluoromethyl)pyrrolidine-1-carboxylate (CAS 460748-84-9)
- 2-Methyl-1-(2-phenoxyethyl)-1H-indole-3-carbaldehyde (CAS 340318-64-1)
- Liraglutide Impurity 30 (CAS CATO-C4X-199230)
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