Carfilzomib Impurity 55 CAS 2177287-70-4

Description

Compared with other compounds in its class, the molecular weight of 255.35 g/mol gives Carfilzomib Impurity 55 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Carfilzomib Impurity 55 (CAS 2177287-70-4) is a certified pharmaceutical impurity reference standard with the molecular formula C14H25NO3 and a molecular weight of 255.35 g/mol.

Carfilzomib Impurity 55 (C14H25NO3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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