2-Chloro-5-(difluoromethyl)pyridine-3,4-diamine CAS 1805951-63-6
| CAS No. | 1805951-63-6 |
| Molecular Formula | C6H6ClF2N3 |
| Molecular Weight | 193.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Chloro-5-(difluoromethyl)pyridine-3,4-diamine is closely related to a nitrile group, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-Chloro-5-(difluoromethyl)pyridine-3,4-diamine (CAS 1805951-63-6), molecular formula C6H6ClF2N3 and molecular weight 193.58 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Chloro-5-(difluoromethyl)pyridine-3,4-diamine (C6H6ClF2N3) is characterized by a nitrile group, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H6ClF2N3 |
| Molecular Weight | 193.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 2-Chloro-4-(difluoromethoxy)aniline (CAS 1247745-21-6)
- 4-Chloro-2-(difluoromethoxy)aniline (CAS 1250677-10-1)
- 2-Chloro-3-(difluoromethoxy)aniline (CAS 1261566-94-2)
- 3-Chloro-5-(difluoromethoxy)aniline (CAS 1261849-95-9)
- 2-Chloro-5-(difluoromethoxy)-3-methylpyridine (CAS 1315360-83-8)
- 2-Chloro-4-(difluoromethyl)-6-methoxypyridine (CAS 1446786-33-9)
- 5-chloro-2-(2,2-difluoroethoxy)pyridine (CAS 1553333-96-2)
- 2-Chloro-4-(2,2-difluoroethoxy)pyridine (CAS 1556698-90-8)
Recommended Standards
- 4-Chloro-6-(difluoromethyl)-2-hydroxy-3-methylpyridine (CAS 1805413-01-7)
- 2-Chloro-5-(difluoromethyl)-3-methoxypyridine (CAS 1806760-58-6)
- 6-Chloro-2-(difluoromethyl)-5-methylpyridin-3-ol (CAS 1805412-96-7)
- 4-Chloro-3-(difluoromethyl)-2-methoxypyridine (CAS 1806760-89-3)
- 6-Bromo-2-(difluoromethyl)isoquinolin-1(2H)-one (CAS 864867-08-3)
- 5-Acetyl-2-fluorobenzeneboronic acid pinacol ester, 97% (CAS 765916-70-9)
- 2-[(4-Bromophenyl)sulfanyl]-6-(3,4-dichlorophenyl)pyridine-3-carbonitrile (CAS 252059-66-8)
- 2-(2-((3-Bromobenzyl)amino)ethoxy)ethan-1-ol (CAS 861410-66-4)
- 3,4-Difluoro-2,5-Thiophenedione (CAS 142453-19-8)
- 2,4-dimethylpyridine-3-carbaldehyde (CAS 168072-32-0)
- 2-(2-Benzylphenoxy)-N-(1-cyanocyclohexyl)acetamide (CAS 791131-91-4)
- (2,4-Difluorophenyl)(thiazol-2-yl)methanone (CAS 1443345-59-2)
- (E)-3-(Perfluorophenyl)acrylic acid (CAS 34234-46-3)
- Liraglutide Impurity 15 TFA Salt (CAS CATO-C4X-199215)
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