Empagliflozin Impurity 31 CAS 1806-23-1
| CAS No. | 1806-23-1 |
| Molecular Formula | C13H8ClFO |
| Molecular Weight | 234.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Empagliflozin Impurity 31 (CAS 1806-23-1, C13H8ClFO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Empagliflozin Impurity 31 (C13H8ClFO) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H8ClFO |
| Molecular Weight | 234.65 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 169 (CAS 637-87-6)
- Empagliflozin Impurity 153 (CAS 219823-47-9)
- Empagliflozin Impurity 93 (CAS 19932-79-7)
- Empagliflozin Impurity 285 (CAS CATO-C4X-1065285)
- Empagliflozin Impurity 164 (CAS CATO-C4X-1065164)
- Empagliflozin Impurity 174 (CAS 270903-87-2)
- Empagliflozin Impurity 33 (CAS CATO-C4X-106533)
- Empagliflozin Impurity 173 (CAS 46698-24-2)
Recommended Standards
- 6-(Chlorodifluoromethyl)-2-mercapto-4-methylnicotinonitrile (CAS 832740-39-3)
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- 4'-Chloro-5-fluoro-[1,1'-biphenyl]-2-carbaldehyde (CAS 60424-47-7)
- Cefaclor Impurity C10 (CAS 108260-07-7)
- Brinzolamide Impurity 23 (CAS CATO-C4X-194023)
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- 2,4-Dichloro-6-(methylsulfonyl)-1,3,5-triazine (CAS 89280-16-0)
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