Empagliflozin Impurity 169 CAS 637-87-6
| CAS No. | 637-87-6 |
| Molecular Formula | C6H4ClI |
| Molecular Weight | 238.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Empagliflozin Impurity 169.
Empagliflozin Impurity 169 (CAS 637-87-6) is a certified pharmaceutical impurity reference standard with the molecular formula C6H4ClI and a molecular weight of 238.45 g/mol.
The molecular framework of Empagliflozin Impurity 169 (C6H4ClI) is characterized by chlorine/iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4ClI |
| Molecular Weight | 238.45 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl/I-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 31 (CAS 1806-23-1)
- Empagliflozin Impurity 153 (CAS 219823-47-9)
- Empagliflozin Impurity 285 (CAS CATO-C4X-1065285)
- Empagliflozin Impurity 93 (CAS 19932-79-7)
- Empagliflozin Impurity 164 (CAS CATO-C4X-1065164)
- Empagliflozin Impurity 174 (CAS 270903-87-2)
- Empagliflozin Impurity 33 (CAS CATO-C4X-106533)
- Empagliflozin Impurity 173 (CAS 46698-24-2)
Recommended Standards
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- Naproxen Impurity 41 (CAS CATO-C4X-170841)
- Ceritinib Impurity 12 (CAS CATO-C4X-1048912)
- Nicergoline EP Impurity H (CAS 192504-81-7)
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- 3-Amino-3-cyclopropyl-2,2-difluoropropan-1-ol (CAS 1337503-55-5)
- (E)-N'-(2-Bromo-5-methoxybenzylidene)-2-(trifluoromethyl)benzenesulfonohydrazide (CAS 2301998-94-5)
- {[5-(3-methylphenyl)thiophen-2-yl]methyl}(propan-2-yl)amine hydrochloride (CAS 1221724-39-5)
- 4-Bromo-2-(((4-chlorophenyl)imino)methyl)-6-methoxyphenol (CAS 338417-07-5)
- Insulin Lispro (CAS 133107-64-9)
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