2-Bromo-5-(difluoromethyl)-6-hydroxynicotinic acid CAS 1806068-18-7
| CAS No. | 1806068-18-7 |
| Molecular Formula | C7H4BrF2NO3 |
| Molecular Weight | 268.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Bromo-5-(difluoromethyl)-6-hydroxynicotinic acid (CAS 1806068-18-7), molecular formula C7H4BrF2NO3 and molecular weight 268.01 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C7H4BrF2NO3, 2-Bromo-5-(difluoromethyl)-6-hydroxynicotinic acid contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 268.01 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4BrF2NO3 |
| Molecular Weight | 268.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 2-Bromo-1-(difluoromethoxy)-3-nitrobenzene (CAS 1174315-54-8)
- 1-Bromo-3-(difluoromethoxy)-5-nitrobenzene (CAS 1261441-47-7)
- 4-Bromo-1-(difluoromethoxy)-2-nitrobenzene (CAS 1261552-41-3)
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- 3-Bromo-2-fluoro-5-(trifluoromethyl)benzonitrile (CAS 133013-32-8)
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- 6-Bromo-5-(difluoromethyl)-4-hydroxypicolinic acid (CAS 1804652-86-5)
- 4-Bromo-5-(difluoromethyl)-3-hydroxypicolinic acid (CAS 1804652-97-8)
Recommended Standards
- 4-Bromo-3-(difluoromethyl)-6-hydroxypicolinic acid (CAS 1805411-86-2)
- 4-Bromo-6-(difluoromethyl)-5-hydroxypicolinic acid (CAS 1806068-27-8)
- 6-Bromo-5-(difluoromethyl)-2-hydroxynicotinic acid (CAS 1805411-00-0)
- 1-(Bromodifluoromethoxy)-4-nitrobenzene (CAS 81932-04-9)
- 4-(Dimethylamino)-2-(1H-1,2,4-triazol-1-yl)nicotinonitrile (CAS 303986-31-4)
- 5,7-Diphenyl-1,3-diazaadamantan-6-one (CAS 19066-35-4)
- (2-(Bromomethyl)-3-methylbutyl)cyclopentane (CAS 1496207-63-6)
- 3-Amino-1-(pyrrolidin-1-yl)propan-1-one (CAS 160687-46-7)
- N-[(4-Methylphenyl)sulfonyl]glutaric acid (CAS 200806-94-6)
- [(2,4-dichlorophenyl)(pyridin-3-yl)methyl](ethyl)amine (CAS 1304390-10-0)
- 1-Allyl-N-(3,4-dichlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (CAS 339027-47-3)
- Dimethyl furan-2,4-dicarboxylate (CAS 1710-13-0)
- 1-(Thiophen-2-ylmethyl)piperidine-4-carbaldehyde (CAS 926921-80-4)
- Insulin Degludec Impurity 27 (CAS CATO-C4X-215727)
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