2-Bromo-3-(difluoromethyl)-5-hydroxyisonicotinonitrile CAS 1806840-65-2
| CAS No. | 1806840-65-2 |
| Molecular Formula | C7H3BrF2N2O |
| Molecular Weight | 249.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 2-Bromo-3-(difluoromethyl)-5-hydroxyisonicotinonitrile (CAS 1806840-65-2), a certified reference material (molecular formula C7H3BrF2N2O, MW 249.01 g/mol) for analytical method development and quality control.
The molecular framework of 2-Bromo-3-(difluoromethyl)-5-hydroxyisonicotinonitrile (C7H3BrF2N2O) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H3BrF2N2O |
| Molecular Weight | 249.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
- 5-Bromo-3,3-difluoro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one (CAS 1393540-54-9)
- 2-Bromo-5-(difluoromethyl)-3-hydroxyisonicotinonitrile (CAS 1805009-61-3)
- 6-Bromo-4-(difluoromethyl)-5-hydroxypicolinonitrile (CAS 1805009-85-1)
- 4-Bromo-3-cyano-2-(difluoromethyl)-6-hydroxypyridine (CAS 1805010-18-7)
- 2-Bromo-5-(difluoromethyl)-4-hydroxynicotinonitrile (CAS 1805229-39-3)
- 2-Bromo-5-(difluoromethyl)-6-hydroxynicotinonitrile (CAS 1805229-45-1)
- 6-Bromo-3-(difluoromethyl)-5-hydroxypicolinonitrile (CAS 1805229-77-9)
- 2-Bromo-3-(difluoromethyl)-6-hydroxyisonicotinonitrile (CAS 1805437-65-3)
Recommended Standards
- 6-Bromo-5-(difluoromethyl)-2-hydroxynicotinonitrile (CAS 1806042-73-8)
- 6-Bromo-5-(difluoromethyl)-3-hydroxypicolinonitrile (CAS 1806840-84-5)
- 5-Bromo-6-(difluoromethoxy)nicotinonitrile (CAS 1805591-98-3)
- 4-Bromo-3-(difluoromethyl)-6-hydroxypicolinonitrile (CAS 1806841-03-1)
- Methyl 2-(4-amino-2,6-dichlorophenyl)acetate (CAS 88135-26-6)
- 5-Methyl-4-phenylthiophene-3-carbohydrazide (CAS 438216-06-9)
- (1-(Piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(pyrrolidin-1-yl)methanone (CAS 1479610-63-3)
- 3-Amino-1H-indazole-6-carboxylic acid (CAS 871709-92-1)
- 5-(Pyridin-3-yl)-1-(3-(trifluoromethoxy)phenyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1340834-14-1)
- 1-(3,3,5,5-Tetramethyl-1,2,3,5,6,7-hexahydro-s-indacen-1-yl)ethanone (CAS 28805-35-8)
- 6-(Difluoromethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine (CAS 2306268-49-3)
- 2-Cyclohexylideneacetonitrile (CAS 4435-18-1)
- 2-Bromo-4-(2-chlorophenyl)-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-9-methanol (CAS 62551-41-1)
- Semaglutide Main Chain P29 (CAS 1169630-82-3)
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