4-(Difluoromethyl)-6-hydroxy-3-nitropyridine-2-sulfonamide CAS 1807003-92-4
| CAS No. | 1807003-92-4 |
| Molecular Formula | C6H5F2N3O5S |
| Molecular Weight | 269.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Difluoromethyl)-6-hydroxy-3-nitropyridine-2-sulfonamide.
CATO supplies 4-(Difluoromethyl)-6-hydroxy-3-nitropyridine-2-sulfonamide (CAS 1807003-92-4), a certified reference material (molecular formula C6H5F2N3O5S, MW 269.18 g/mol) for analytical method development and quality control.
Based on its molecular formula C6H5F2N3O5S, 4-(Difluoromethyl)-6-hydroxy-3-nitropyridine-2-sulfonamide contains a carbohydrate-derived structure, an amide group, a sulfone group, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 269.18 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5F2N3O5S |
| Molecular Weight | 269.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Difluoromethyl Standards
- 2-(Difluoromethyl)-5-hydroxy-4-nitropyridine-3-sulfonamide (CAS 1805094-04-5)
- 2-(Difluoromethyl)-3-hydroxy-5-nitropyridine-4-sulfonamide (CAS 1805618-32-9)
- 4-(Difluoromethyl)-5-hydroxy-3-nitropyridine-2-sulfonamide (CAS 1807004-09-6)
- 2-(Difluoromethyl)-6-hydroxy-3-nitropyridine-5-sulfonamide (CAS 1807123-72-3)
- 4-(Difluoromethyl)-6-hydroxy-5-nitropyridine-3-sulfonamide (CAS 1807123-79-0)
- 4-(difluoromethyl)-2-(4-methoxyphenyl)-1,3-oxazole-5-carboxylic acid (CAS 1803584-52-2)
- Ethyl 2-(difluoromethyl)-5-oxo-5,6,7,8-tetrahydroquinoline-3-carboxylate (CAS 1708288-63-4)
- 2-(Difluoromethyl)-6-methylpyridine-4-boronic Acid Pinacol Ester (CAS 1321518-16-4)
Recommended Standards
- (1-(3-Bromophenyl)cyclohexyl)methanol (CAS 1781895-37-1)
- 1-((5-Bromopyridin-2-yl)methyl)azepane (CAS 1708414-70-3)
- (1-(4-Bromophenyl)-3,3-dimethylcyclobutyl)methanol (CAS 2090995-15-4)
- 1,2,3-Trifluoro-5-(4-nitrophenoxy)benzene (CAS 1706437-46-8)
- 3,3-Dibenzyl-1-methyl-2-pyrrolidinone (CAS 1290070-60-8)
- tert-Butyl D-alanylglycinate (CAS 74098-65-0)
- 2-((Butyl(methyl)amino)methyl)benzaldehyde (CAS 1443310-53-9)
- 1H-Indol-2-amine hydrochloride (CAS 27878-37-1)
- N-Cyclopropyl-N-(2-((2-hydroxyethyl)amino)cyclohexyl)acetamide (CAS 1353965-12-4)
- 2-Methylquinoline-5-carboxamide (CAS 103011-86-5)
- N-[[[2-Nitro-5-(propylthio)phenyl]amino]thioxomethyl]carbamic Acid Methyl Ester (CAS 65671-10-5)
- 1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-sulfonyl chloride (CAS 1235439-97-0)
- Clenbuterol impurity 12 (CAS CATO-C4X-199312)
- Prolactin-Releasing Peptide (1-31) (human) (CAS 215510-22-8)
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