Edoxaban Impurity 40 (1S,2R,4S) Mesylate CAS 1807315-98-5
| CAS No. | 1807315-98-5 |
| Molecular Formula | C16H22ClN5O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 463.93 g/mol gives Edoxaban Impurity 40 (1S,2R,4S) Mesylate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Edoxaban Impurity 40 (1S,2R,4S) Mesylate (CAS 1807315-98-5, C16H22ClN5O3CH4O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C16H22ClN5O3CH4O3S, Edoxaban Impurity 40 (1S,2R,4S) Mesylate contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 463.93 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H22ClN5O3 CH4O3S |
| Molecular Weight | 463.93 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Edoxaban Standards
- Edoxaban Impurity 73 (CAS 1057651-37-2)
- Edoxaban Impurity 7 (CAS 1072-98-6)
- Edoxaban Impurity 71 (CAS 1093351-29-1)
- Edoxaban Impurity N8 HCl (CAS 1190971-73-3)
- Edoxaban Impurity 47 (CAS 1210348-16-5)
- Edoxaban Impurity 74 (CAS 1210348-21-2)
- Edoxaban Impurity 20 (CAS 1210348-34-7)
- Edoxaban Tosylate Monohydrate (CAS 1229194-11-9)
Recommended Standards
- Dapagliflozin Impurity 196 (CAS CATO-C4X-1138196)
- Phenoxymethylpenicillin EP Impurity E HCl（Penicilloic acids of phenoxymethylpenicillin） (CAS 1049-84-9 (free base))
- Baloxavir Impurity 34 (CAS 2136287-66-4)
- 3-(4-Aminopiperidin-1-yl)benzo[d]isothiazole 1,1-dioxide (CAS 1152984-22-9)
- Diethyl hexylphosphonate (CAS 16165-66-5)
- 1,4-Dimethyl-N-((1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)-1H-pyrazol-5-amine hydrochloride (CAS 1856064-51-1)
- 3-Amino-1-(benzyloxy)piperidine-2,6-dione hydrochloride (CAS 2768493-73-6)
- 1-(Indolin-1-yl)-3-(2-methyl-4-(thiophen-2-yl)thiazol-5-yl)propan-1-one (CAS 1049132-49-1)
- Acequinocyl-Hydroxy (CAS 57960-31-3)
- (Tyr?)-C-Peptide (dog) (CAS 101135-67-5)
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