Aprepitant Impurity 70 CAS 419574-15-5
| CAS No. | 419574-15-5 |
| Molecular Formula | C22H20F7NO4 |
| Molecular Weight | 495.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Aprepitant Impurity 70 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Aprepitant Impurity 70 (CAS 419574-15-5), a pharmacopoeial impurity reference standard (molecular formula C22H20F7NO4, MW 495.39 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Aprepitant Impurity 70 (C22H20F7NO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H20F7NO4 |
| Molecular Weight | 495.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant Impurity 69 (CAS 178616-88-1)
- Aprepitant Impurity 81 (CAS CATO-C4X-114181)
- Aprepitant Impurity 32 (CAS CATO-C4X-116832)
- Aprepitant impurity 55 (CAS CATO-C4X-114155)
- Aprepitant EP Impurity A (CAS 170729-76-7)
- Aprepitant impurity 29 (CAS CATO-C4X-237929)
- Aprepitant Impurity 44 (CAS CATO-C4X-114144)
- Aprepitant impurity 56 (CAS CATO-C4X-114156)
Recommended Standards
- N-(2,4-Difluorophenyl)-1-methyl-3-(trifluoromethyl)-5-({[3-(trifluoromethyl)phenyl]methyl}sulfanyl)-1H-pyrazole-4-carboxamide (CAS 321553-24-6)
- Bromodesonide (CAS CATO-C4X-13013)
- 2-((5-(2-Bromophenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-methoxyphenyl)acetamide (CAS 332934-90-4)
- Betamethasone Impurity 43 (CAS 4735-65-3)
- Diazoxide Impurity 20 (CAS CATO-C4X-195220)
- Nebivolol Impurity 13（SR,SR） (CAS CATO-C4X-196813)
- Amlodipine impurity 130 (CAS CATO-C4X-1095130)
- Terbinafine impurity 42 (CAS CATO-C4X-133842)
- 2-Chloro-alpha,alpha-dimethyl-benzenepropanal (CAS 278615-09-1)
- 5,5'-(Pyridine-2,6-diyl)diisophthalic acid (CAS 1426343-47-6)
- Ethyl (3R,4S)-1-benzyl-4-(2-chloro-6-fluorophenyl)pyrrolidine-3-carboxylate (CAS 2327184-32-5)
- 6-Chloro-N-ethylpyridin-2-amine (CAS 89026-80-2)
- Ethyl 2,3-dihydro-1H-imidazo[1,2-b]pyrazole-7-carboxylate (CAS 1378779-72-6)
- D-[His]1-Semaglutide (CAS CATO-C4X-222652)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com