Omarigliptin Impurity 12 CAS 1819364-05-0
| CAS No. | 1819364-05-0 |
| Molecular Formula | C22H28F2N4O5S |
| Molecular Weight | 498.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 498.54 g/mol gives Omarigliptin Impurity 12 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Omarigliptin Impurity 12 (CAS 1819364-05-0) is a certified pharmaceutical impurity reference standard with the molecular formula C22H28F2N4O5S and a molecular weight of 498.54 g/mol.
Omarigliptin Impurity 12 (C22H28F2N4O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Omarigliptin Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H28F2N4O5S |
| Molecular Weight | 498.54 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Omarigliptin Standards
- Omarigliptin Impurity 4 (CAS 1226781-87-8)
- Omarigliptin (CAS 1226781-44-7)
- Omarigliptin Impurity 13 (CAS 1443380-88-8)
- Omarigliptin Impurity 14 (CAS CATO-C4X-114714)
- Omarigliptin Impurity 15 (CAS CATO-C4X-114715)
- Omarigliptin Impurity 17 (CAS CATO-C4X-114717)
- Omarigliptin Impurity 18 (CAS CATO-C4X-114718)
- Omarigliptin Impurity 2 (CAS 1172623-99-2)
Recommended Standards
- WYE 354-d3 (CAS 1794791-66-4)
- Fmoc-Tyr-Ala-diazomethylketone (CAS 205763-22-0)
- 2-(1,5-Dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide (CAS 1928707-56-5)
- Boc-Thr(Gly-Fmoc)-OH (CAS 944283-25-4)
- Levocarnitine Impurity 10 (CAS CATO-C4X-129210)
- Bumetanide Impurity 47 (CAS CATO-C4X-198647)
- Neostigmine bromide Impurity 14 (CAS 14318-66-2)
- 2-(Difluoromethyl)-3-fluoro-5-methoxypyridine-6-carbonyl chloride (CAS 1804951-42-5)
- 2,5,6-Trimethyl-1-(3-methylbenzyl)-1H-benzo[d]imidazol-4-amine (CAS 338954-75-9)
- (5-Bromo-2-ethoxyphenyl)methanamine (CAS 887582-48-1)
- Boc-Val-ONp (CAS 16948-40-6)
- tert-Butyl 2-benzyl-2,7-diazaspiro[3.5]nonane-7-carboxylate (CAS 1206969-92-7)
- N-(4-Bromo-2-chlorophenyl)tetrahydro-2H-pyran-4-amine (CAS 1056465-04-3)
- Neuropeptide EI (human, mouse, rat) (CAS 125934-45-4)
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