Omarigliptin Impurity 2 CAS 1172623-99-2
| CAS No. | 1172623-99-2 |
| Molecular Formula | C16H21F2NO4 |
| Molecular Weight | 329.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Omarigliptin Impurity 2 (CAS 1172623-99-2) is a certified pharmaceutical impurity reference standard with the molecular formula C16H21F2NO4 and a molecular weight of 329.34 g/mol.
Omarigliptin Impurity 2 (C16H21F2NO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H21F2NO4 |
| Molecular Weight | 329.34 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Omarigliptin Standards
- Omarigliptin Impurity 3 (CAS 951127-25-6)
- Omarigliptin Impurity 4 (CAS 1456616-42-4)
- Omarigliptin Impurity 5 (CAS 1456616-44-6)
- Omarigliptin Impurity 6 (CAS 1456616-43-5)
- Omarigliptin Impurity 7 (CAS CATO-C4X-11477)
- Omarigliptin Impurity 8 (CAS CATO-C4X-11478)
- Omarigliptin Impurity 16 (CAS 1819364-01-6)
- Omarigliptin Impurity 1 (CAS 1172623-98-1)
Recommended Standards
- 5-Methoxy-N,N-dimethyl-4-((3-(trifluoromethyl)phenyl)thio)pyrimidin-2-amine (CAS 400083-96-7)
- 2-((3,4-Dimethoxyphenethyl)carbamoyl)benzoic acid (CAS 101730-66-9)
- 3-((3-Cyano-4-(trifluoromethyl)-5,6,7,8-tetrahydroquinolin-2-yl)thio)propanamide (CAS 905787-17-9)
- N-(6-((2-Fluorobenzyl)thio)pyridazin-3-yl)furan-2-carboxamide (CAS 1021106-79-5)
- Relugolix Impurity 212 (CAS CATO-C4X-2429212)
- Progesterone Impurity 38 (CAS 19289-77-1)
- Rivaroxaban Impurity 53 (CAS CATO-C4X-109053)
- 1-Bromo-2,4-dichloro-3-methylbenzene (CAS 127049-87-0)
- (2-Fluoro-6-(methoxymethoxy)phenyl)boronic acid (CAS 2121511-85-9)
- 2-(3-Cyclopropyl-4-(difluoromethyl)-6-(4-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid (CAS 937607-32-4)
- (Perfluoroprop-1-en-2-yl)benzene (CAS 1979-51-7)
- 2-Ethynyl-5,8-dioxaspiro[3.4]octane (CAS 1392803-25-6)
- (R)-1-((R)-1-(4-Methoxyphenyl)ethyl)-4-propionylpyrrolidin-2-one (CAS 1650544-72-1)
- Cyclopeptide-5 (CAS 197172-76-2)
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