Fluorouracil EP Impurity E CAS 1820-81-1
| CAS No. | 1820-81-1 |
| Molecular Formula | C4H3ClN2O2 |
| Molecular Weight | 146.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Fluorouracil EP Impurity E (CAS 1820-81-1, C4H3ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Fluorouracil EP Impurity E (C4H3ClN2O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Fluorouracil EP Impurity E under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C4H3ClN2O2 |
| Molecular Weight | 146.53 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Fluorouracil Standards
- Fluorouracil Impurity 26 (CAS 62836-98-0)
- Fluorouracil Impurity 12 (CAS 155-16-8)
- Fluorouracil Impurity 11 (Mixture of Diastereomers) (CAS 37103-91-6)
- Fluorouracil Impurity 3 (CAS 4840-69-1)
- Fluorouracil Impurity 10 (CAS 1480-96-2)
- Fluorouracil EP Impurity D (CAS 6623-81-0)
- Fluorouracil Impurity 22 (CAS CATO-C4X-164922)
- Fluorouracil Impurity 30 (CAS CATO-C4X-164930)
Recommended Standards
- Alogliptin Impurity 57 (CAS 4270-27-3)
- 2-Amino-4-hydroxy-6-chloro-s-triazine (CAS 38862-29-2)
- Ceritinib Impurity 77 (CAS CATO-C4X-104877)
- 4-Chloro-1,1,1-trifluorobutane (CAS 406-85-9)
- Calcitriol Impurity 60 (CAS CATO-C4X-151060)
- Etelcalcetide Impurity 22 X TFA Salt (CAS CATO-C4X-324722)
- Lenvatinib Impurity 117 (CAS 1565657-07-9)
- N-(3-bromophenyl)-4-((2-chlorothiazol-5-yl)methoxy)benzenesulfonamide (CAS 339105-51-0)
- N-(2-Methyl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-yl)benzamide (CAS 827598-52-7)
- Ethyl 2,4-dioxo-6-phenylhex-5-enoate (CAS 1027-41-4)
- Cis-9-hexadecenyl acetate (CAS 34010-20-3)
- 3-Phenyl-2H-pyrido[1,2-a]pyrimidine-2,4(3H)-dione (CAS 61760-26-7)
- tert-Butyl (2S)-2-(aminomethyl)-2-isobutyl-pyrrolidine-1-carboxylate (CAS 1638744-17-8)
- Semaglutide impurity 250 (CAS CATO-C4X-2226250)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com