Alogliptin Impurity 57 CAS 4270-27-3
| CAS No. | 4270-27-3 |
| Molecular Formula | C4H3ClN2O2 |
| Molecular Weight | 146.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Alogliptin Impurity 57 is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 146.53 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Alogliptin Impurity 57 (CAS 4270-27-3) is a certified pharmaceutical impurity reference standard with the molecular formula C4H3ClN2O2 and a molecular weight of 146.53 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Alogliptin Impurity 57 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H3ClN2O2 |
| Molecular Weight | 146.53 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Alogliptin Standards
- Alogliptin Impurity 42 (CAS 400840-94-0)
- Alogliptin Impurity 69 (CAS 1243378-31-5)
- Alogliptin Related Compound 49 (CAS 33832-98-3)
- Alogliptin Impurity 63 (CAS 147754-12-9)
- Alogliptin Impurity 36 (CAS 4318-56-3)
- Alogliptin Related Compound 81 (CAS 7468-67-9)
- Alogliptin impurity 74 (CAS 2819242-71-0)
- Alogliptin Related Compound 33 (CAS 4187-53-5)
Recommended Standards
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- Sildenafil Impurity 30 (CAS 139755-95-6)
- Doxycycline EP Impurity E (CAS 79-57-2)
- Aprepitant Impurity 75 (CAS 240489-98-9)
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