Flurbiprofen Impurity 146 CAS 1821192-15-7
| CAS No. | 1821192-15-7 |
| Molecular Formula | C30H25FO4 |
| Molecular Weight | 468.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Flurbiprofen Impurity 146 is closely related to a steroid core, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Flurbiprofen Impurity 146 (CAS 1821192-15-7), a pharmacopoeial impurity reference standard (molecular formula C30H25FO4, MW 468.52 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Flurbiprofen Impurity 146 (C30H25FO4) contains a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 18.0, corresponding to approximately 18 ring(s) or double-bond equivalent(s). With a molecular weight of 468.52 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Flurbiprofen Impurity 146 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C30H25FO4 |
| Molecular Weight | 468.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
Related Flurbiprofen Standards
- Flurbiprofen Impurity 62 (CAS CATO-C4X-144462)
- Flurbiprofen Impurity 98 (CAS CATO-C4X-144498)
- Flurbiprofen Impurity 125 (CAS CATO-C4X-1444125)
- Flurbiprofen Impurity 131 (CAS CATO-C4X-1444131)
- Flurbiprofen Impurity 132 (CAS CATO-C4X-1444132)
- Flurbiprofen Impurity 95 (CAS CATO-C4X-144495)
- Flurbiprofen Impurity 107 (CAS CATO-C4X-1444107)
- Flurbiprofen Impurity 134 (CAS CATO-C4X-1444134)
Recommended Standards
- Cefdinir Impurity 36 (CAS CATO-C4X-121036)
- Paliperidone Impurity 80 (CAS 130049-87-5)
- tert-butyl 4-(4-((8-ethyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-2-fluorophenyl)piperazine-1-carboxylate (CAS 2443767-09-5)
- N-(4-((4-(3-(benzo[d][1,3]dioxol-5-yl)-1H-pyrazol-5-yl)piperidin-1-yl)sulfonyl)phenyl)acetamide (CAS 1030386-41-4)
- Letermovir Impurity 83 (CAS CATO-C4X-291583)
- Cimetidine impurity 24 (CAS CATO-C4X-158924)
- Fluvoxamine Impurity 14 (CAS CATO-C4X-195114)
- (3R)-N-{3,6-dichloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl}piperidin-3-amine (CAS 1980007-49-5)
- (Z)-N-Cyclopropyl-alpha,beta-Dimethyl-4-Fluorocinnamamide (CAS 60548-43-8)
- 6-Fluoro-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one (CAS 1242014-94-3)
- (3-(4-Bromophenyl)-1-(3-chloro-4-fluorophenyl)-1H-pyrazol-4-yl)methanol (CAS 618383-29-2)
- Emedastine impurity 35 (CAS CATO-C4X-226735)
- Tert-butyl 2-cyano-4-methylpyrrolidine-1-carboxylate (CAS 955016-21-4)
- Neuropeptide VF (124-131) (human) (CAS 311309-27-0)
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