Azilsartan Impurity 8 CAS 1821386-21-3
| CAS No. | 1821386-21-3 |
| Molecular Formula | C22H18N4O4 |
| Molecular Weight | 402.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Azilsartan Impurity 8 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Azilsartan Impurity 8 (CAS 1821386-21-3), a pharmacopoeial impurity reference standard (molecular formula C22H18N4O4, MW 402.40 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Azilsartan Impurity 8 (C22H18N4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 402.40 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H18N4O4 |
| Molecular Weight | 402.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 4 |
Related Azilsartan Standards
- Azilsartan Impurity 104 (CAS CATO-C4X-1096104)
- Azilsartan Impurity 185 (CAS CATO-C4X-1096185)
- Azilsartan impurity 143 (CAS CATO-C4X-1096143)
- Azilsartan impurity 144 (CAS CATO-C4X-1096144)
- Azilsartan Impurity 18 (CAS 2171316-29-1)
- Azilsartan Impurity 21 (CAS 136285-67-1)
- Azilsartan Impurity 109 (CAS CATO-C4X-1096109)
- Azilsartan Impurity 11 (CAS CATO-C4X-109611)
Recommended Standards
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- Methyl 2-amino-2-(methoxymethyl)butanoate (CAS 1343369-63-0)
- N2-Lauroyl-L-glutamine (CAS 109570-04-9)
- Ethyl (4-(2-((2-methoxy-5-methylphenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate (CAS 946314-53-0)
- Sitagliptin Impurity 7 (CAS 767352-30-7)
- 2-Amino-3-(trifluoromethyl)cyclopropane-1-carboxylic acid (CAS 1240526-67-3)
- Neuropeptide Y (1-24) amide (human, rat) (CAS 131448-51-6)
Why CATO?
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com