Amlodipine Impurity 14 CAS 1821498-25-2
| CAS No. | 1821498-25-2 |
| Molecular Formula | C17H19ClN2O5 |
| Molecular Weight | 366.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Amlodipine Impurity 14 (C17H19ClN2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Amlodipine Impurity 14 (CAS 1821498-25-2) is a certified pharmaceutical impurity reference standard with the molecular formula C17H19ClN2O5 and a molecular weight of 366.80 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Amlodipine Impurity 14 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H19ClN2O5 |
| Molecular Weight | 366.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Amlodipine Standards
- Amlodipine Impurity 53 (CAS CATO-C4X-109553)
- Amlodipine Impurity 63 (CAS 79781-21-8)
- Amlodipine Impurity 23 (CAS 34148-67-9)
- Amlodipine Impurity 71 (CAS 114011-50-6)
- Amlodipine Impurity 115 (CAS 20236-47-9)
- Amlodipine Impurity 75 (CAS 113994-44-8)
- Amlodipine Impurity 138 (CAS CATO-C4X-1095138)
- Amlodipine Impurity 18 (CAS 1809326-44-0)
Recommended Standards
- N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-N-(2-methoxyethyl)acetamide (CAS 568555-81-7)
- Atorvastatin Impurity 144 (CAS CATO-C4X-1132144)
- MLN120B, 99%, a specific, ATP competitive IKKβ inhibitor with an IC50 of 60 nM (CAS 783348-36-7)
- 2-Chloro-5-(4-(pyrrolidin-1-ylsulfonyl)phenyl)isonicotinic acid (CAS 1261924-38-2)
- Pitavastatin Impurity 73 (CAS CATO-C4X-103773)
- Flupentixol Impurity 45 (CAS CATO-C4X-189545)
- Apremilast impurity 91 HCl (CAS 311310-97-1)
- Ly210073 (CAS 148291-65-0)
- 3-Methyl-3,4,4-trichlorobenzophenone (CAS 951891-35-3)
- 1-Propenyl-3-methylimidazolium nitrate (CAS 649745-76-6)
- Nemonoxacin Impurity 71 (CAS 1203651-06-2)
- 4-(Difluoromethyl)-6-hydroxy-5-methylnicotinoyl chloride (CAS 1806973-94-3)
- Ethyl 1-Boc-3-allylpiperidine-3-carboxylate (CAS 374795-32-1)
- FLAG Epitope Peptide (CAS 98849-88-8)
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