Amlodipine Impurity 115 CAS 20236-47-9
| CAS No. | 20236-47-9 |
| Molecular Formula | C22H30O4 |
| Molecular Weight | 358.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Amlodipine Impurity 115 (CAS 20236-47-9, C22H30O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Amlodipine Impurity 115 (C22H30O4) contains a flavonoid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 358.47 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H30O4 |
| Molecular Weight | 358.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
Related Amlodipine Standards
- Amlodipine Impurity 138 (CAS CATO-C4X-1095138)
- Amlodipine Impurity 71 (CAS 114011-50-6)
- Amlodipine Impurity 23 (CAS 34148-67-9)
- Amlodipine Impurity 53 (CAS CATO-C4X-109553)
- Amlodipine Impurity 63 (CAS 79781-21-8)
- Amlodipine Impurity 14 (CAS 1821498-25-2)
- Amlodipine Impurity N22 (CAS 39562-06-6)
- Amlodipine Impurity N4 (CAS 113994-36-8)
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