Tofacitinib Impurity 110 DiHCl CAS 1821769-41-8
| CAS No. | 1821769-41-8 |
| Molecular Formula | C14H22N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tofacitinib Impurity 110 DiHCl (CAS 1821769-41-8) is a certified pharmaceutical impurity reference standard with the molecular formula C14H22N2HCl and a molecular weight of 254.80 g/mol.
Based on its molecular formula C14H22N2HCl, Tofacitinib Impurity 110 DiHCl contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 254.80 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H22N2 2*HCl |
| Molecular Weight | 254.80 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Risedronate EP Impurity B Sodium Salt (CAS 105462-23-5（free base）)
- Buspirone Impurity 20 (CAS 1821194-01-7)
- Cefoperazone EP Impurity F (CAS 1315481-36-7)
- Trans-5-methyl-3-(4-nitrophenyl)-4-phenyl-4,5-dihydroisoxazole (CAS 61191-51-3)
- 1-Ethyl-2-mercapto-1H-benzoimidazole-5-sulfonic acid diethylamide (CAS 568570-12-7)
- 5-(3-Methoxyphenyl)-2-methyloxazole (CAS 74048-08-1)
- N,N-dimethyl-2-((pyridin-4-ylmethyl)amino)acetamide (CAS 1042507-76-5)
- 4-(4-Fluorobenzylidene)piperidine (CAS 661452-53-5)
- 2-Imino-1-(2-methoxyethyl)-N-(3-methoxypropyl)-10-methyl-5-oxo-2,5-dihydro-1H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide (CAS 370582-34-6)
- Liraglutide Impurity 17 TFA Salt (CAS CATO-C4X-199217)
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