Methyl 3-chloro-1-methyl-6-oxo-5-(trifluoromethyl)-1,6-dihydro-[2,3-bipyridine]-5-carboxylate CAS 1823182-25-7
| CAS No. | 1823182-25-7 |
| Molecular Formula | C14H10ClF3N2O3 |
| Molecular Weight | 346.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Methyl 3-chloro-1-methyl-6-oxo-5-(trifluoromethyl)-1,6-dihydro-[2,3-bipyridine]-5-carboxylate (CAS 1823182-25-7), molecular formula C14H10ClF3N2O3 and molecular weight 346.69 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Methyl 3-chloro-1-methyl-6-oxo-5-(trifluoromethyl)-1,6-dihydro-[2,3-bipyridine]-5-carboxylate (C14H10ClF3N2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Methyl 3-chloro-1-methyl-6-oxo-5-(trifluoromethyl)-1,6-dihydro-[2,3-bipyridine]-5-carboxylate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H10ClF3N2O3 |
| Molecular Weight | 346.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Methyl Standards
- Methyl 3-chloro-6-methoxy-5-(trifluoromethyl)-[2,3-bipyridine]-5-carboxylate (CAS 1823183-87-4)
- 3-Chloro-N-((4,5-dihydro-[3,5'-biisoxazol]-5-yl)methyl)-5-(trifluoromethyl)pyridin-2-amine (CAS 339098-60-1)
- 2-(4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)(methyl)amino)-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)acetonitrile (CAS 860786-19-2)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(5-fluoro-2-methylphenyl)acetamide (CAS 439107-80-9)
- 2-Chloro-4-(methylsulfonyl)-3-((2,2,2-trifluoroethoxy)methyl)benzoic acid (CAS 120100-77-8)
- 1-(2-Chloro-benzyl)-3,5-dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (CAS 2246642-44-2)
- 3-[(E)-2-[(5-Chloro-2-hydroxyphenyl)amino]-1-nitroethenyl]-1,3-dihydro-2-benzofuran-1-one (CAS 320420-38-0)
- 3-Chloro-6-((3-(trifluoromethyl)phenyl)sulfinyl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 303996-28-3)
Recommended Standards
- 4-Chlorobenzyl 2-hydrazinyl-4-(trifluoromethyl)pyrimidine-5-carboxylate (CAS 175137-33-4)
- N-Propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-carbamic Acid Methyl Ester (CAS 1424939-65-0)
- 1-(3-(4-Bromo-2-chlorophenoxy)propyl)-4-methylpiperidine (CAS 401802-68-4)
- 1,2-Didecyldisulfane (CAS 10496-18-1)
- 1-(2-Bromophenyl)cyclopropanecarboxylic Acid (CAS 124276-87-5)
- 3-Chloro-4-(4-fluorophenoxy)aniline (CAS 937608-56-5)
- 4-[(4-Nitrobenzyl)oxy]piperidine hydrochloride (CAS 1426290-64-3)
- 4-(1H-imidazol-4-ylmethyl)phenol (CAS 911701-06-9)
- 2-((6-Oxidodibenzo[c,e][1,2]oxaphosphinin-6-yl)methyl)succinic acid (CAS 63562-33-4)
- (1S,2R)-2-ethynylcyclopropane-1-carboxylic acid (CAS 1491135-70-6)
- 1-(Benzyloxy)-3-(chloromethyl)-5-nitrobenzene (CAS 1393576-95-8)
- Epinastine Impurity 40 (CAS CATO-C4X-184040)
- Benzyl 5-amino-1,3,4-thiadiazole-2-carboxylate (CAS 501082-58-2)
- Uremic Pentapeptide (CAS 71494-20-7)
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