2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-5-fluoro-6-methylpyrimidin-4(3H)-one CAS 1823183-47-6
| CAS No. | 1823183-47-6 |
| Molecular Formula | C11H6ClF4N3O |
| Molecular Weight | 307.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-5-fluoro-6-methylpyrimidin-4(3H)-one (C11H6ClF4N3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-5-fluoro-6-methylpyrimidin-4(3H)-one (CAS 1823183-47-6), molecular formula C11H6ClF4N3O and molecular weight 307.63 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-5-fluoro-6-methylpyrimidin-4(3H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H6ClF4N3O |
| Molecular Weight | 307.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- 5-Bromo-3-chloro-N-(2,2-dimethylthietan-3-yl)pyridin-2-amine (CAS 1870100-35-8)
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- Urapidil impurity 100 (CAS CATO-C4X-1924100)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-5-ethoxy-2,4-dihydro-3H-pyrazol-3-one (CAS 338420-89-6)
- α-Methyl-1, 3-benzodioxole- 5- propanamide (CAS 858215-05-1)
- (1S,2S,5R,6S)-2-Amino-4,4-dimethylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid (CAS 1651825-29-4)
- 4-Amino-4-methyltetrahydro-2H-thiopyran 1,1-dioxide hydrochloride (CAS 1986297-99-7)
- N-(4,5-Dimethoxy-2-(2-phenylacetyl)phenyl)acetamide (CAS 886493-90-9)
- 3,5-Difluoro-4-(trifluoromethyl)pyridin-2-amine (CAS 883498-68-8)
- 2-(Difluoromethyl)-3-nitro-5-(trifluoromethoxy)pyridine-6-acetic acid (CAS 1805203-02-4)
- 8-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-phenyl-1,2,4,8-tetraazaspiro[4.5]decan-3-one (CAS 250713-96-3)
- 2-(6,7-Dimethoxy-2-oxo-1,2,3,4-tetrahydroquinolin-4-yl)acetic acid (CAS 1160264-02-7)
- 3,5-Dimethoxypyridazine (CAS 2096-20-0)
- DAPK Substrate Peptide (CAS 386769-53-5)
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