4,6-difluoro-5-methylpyrimidine CAS 18260-64-5
| CAS No. | 18260-64-5 |
| Molecular Formula | C5H4F2N2 |
| Molecular Weight | 130.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4,6-difluoro-5-methylpyrimidine is closely related to a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4,6-difluoro-5-methylpyrimidine (CAS 18260-64-5), molecular formula C5H4F2N2 and molecular weight 130.10 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4,6-difluoro-5-methylpyrimidine (C5H4F2N2) is characterized by a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H4F2N2 |
| Molecular Weight | 130.10 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related difluoro Standards
- 3,6-Difluoro-4-methylpyridazine (CAS 1026843-07-1)
- 4,6-Difluoro-2-methylpyrimidine (CAS 18382-80-4)
- 2,4-difluoro-5-methylpyrimidine (CAS 96548-89-9)
- 2,4-Difluoro-6-methylpyrimidine (CAS 696-80-0)
- 4,6-Difluoro-2-pyridinamine (CAS 938443-45-9)
- 3,5-Difluoro-1H-pyridin-2-one (CAS 914482-23-8)
- 2,4-Difluoro-5-methylpyridine (CAS 1227502-70-6)
- 2,5-Difluoro-4-methylpyridine (CAS 1227508-13-5)
Recommended Standards
- 5,6-Difluoropyridin-2-amine (CAS 1807159-28-9)
- 3,4-Difluoropyridin-2-amine (CAS 1804379-06-3)
- 2,5-Difluoropyridin-4-amine (CAS 189281-61-6)
- 3,4-Diaminodihydrofuran-2,5-dione (CAS 174700-97-1)
- 121697-55-0 2-(3-Chlorobenzyloxy)benzoic acid C14H11ClO3 Y7259 (CAS 121697-55-0)
- 2-(4,6-Dichloro-5-methylpyrimidin-2-yl)ethan-1-amine hydrochloride (CAS 1196155-46-0)
- 5-Cyclopropoxy-2-ethyl-N-methylisonicotinamide (CAS 1243476-78-9)
- 5-Bromo-4-fluoro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (CAS 1365889-20-8)
- 2-(Aminomethyl)-6-(difluoromethyl)-3-(trifluoromethoxy)pyridine-5-acetonitrile (CAS 1806779-21-4)
- Tert-butyl 3-(hydroxymethyl)-1H-1,2,4-triazole-1-carboxylate (CAS 1142202-21-8)
- 3-Chloro-2-fluoro-5-hydroxypyridine (CAS 209328-72-3)
- 2-Phenyl-1H-indol-6-ol (CAS 62613-58-5)
- 2-Oxo-2-((5-((3-phenylpropyl)thio)-1,3,4-thiadiazol-2-yl)amino)acetic acid (CAS 1158451-21-8)
- Tirzepatide Impurity 16 (CAS CATO-C4X-324016)
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