5-Bromo-4-(chloromethyl)pyrimidine CAS 1849357-49-8
| CAS No. | 1849357-49-8 |
| Molecular Formula | C5H4BrClN2 |
| Molecular Weight | 207.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 207.46 g/mol gives 5-Bromo-4-(chloromethyl)pyrimidine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
5-Bromo-4-(chloromethyl)pyrimidine (CAS 1849357-49-8) is a high-purity analytical reference standard with the molecular formula C5H4BrClN2 and a molecular weight of 207.46 g/mol.
The molecular framework of 5-Bromo-4-(chloromethyl)pyrimidine (C5H4BrClN2) is characterized by a nitrile group, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 5-Bromo-4-(chloromethyl)pyrimidine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C5H4BrClN2 |
| Molecular Weight | 207.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
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- 2-Bromo-5-chloro-3-methylpyrazine (CAS 1260664-82-1)
Recommended Standards
- 4-Bromomethylpyrimidine hydrobromide (CAS 181363-06-4)
- 2-Bromo-5-chloro-4-methylpyrimidine (CAS 1936719-98-0)
- 4-Bromo-5-chloropyridin-3-amine (CAS 1802434-30-5)
- 2-Amino-3-bromo-4-chloropyridine (CAS 221297-82-1)
- 1-(Aminomethyl)-2,2-dimethylcyclopropanecarboxylic acid (CAS 724772-93-4)
- 1,3,5,7-tetrakis(4-formylphenyl)adamantane (CAS 645401-15-6)
- N-(2,4-Dinitrophenyl)glycine (CAS 1084-76-0)
- Roxadustat Impurity N4 (CAS 1421312-33-5)
- Domperidone Impurity 20 (CAS 53786-46-2)
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- 3-Fluoro-4-(3-methoxypropoxy)aniline (CAS 946785-56-4)
- Olaparib Impurity 76 (CAS CATO-C4X-113576)
- 2'-Butoxy-2,6-Diamino-3,5'-Azopyridine (CAS 617-19-6)
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