4-chloro-6-fluoro-2-methylquinoline CAS 18529-01-6
| CAS No. | 18529-01-6 |
| Molecular Formula | C10H7ClFN |
| Molecular Weight | 195.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-chloro-6-fluoro-2-methylquinoline is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-chloro-6-fluoro-2-methylquinoline (CAS 18529-01-6), molecular formula C10H7ClFN and molecular weight 195.62 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 4-chloro-6-fluoro-2-methylquinoline (C10H7ClFN) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 195.62 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7ClFN |
| Molecular Weight | 195.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related chloro Standards
- 4-Chloro-5-fluoro-8-methylquinoline (CAS 1065093-43-7)
- 4-Chloro-6-fluoro-8-methylquinoline (CAS 1065093-47-1)
- 4-Chloro-7-fluoro-8-methylquinoline (CAS 1065093-51-7)
- 2-Chloro-8-fluoro-4-methylquinoline (CAS 1171919-59-7)
- 1-(3-Chloro-4-fluorophenyl)cyclopropanecarbonitrile (CAS 1205640-59-0)
- 1-Chloro-7-fluoro-3-methylisoquinoline (CAS 1206982-03-7)
- 1-(2-Chloro-6-fluorophenyl)cyclopropanecarbonitrile (CAS 124276-45-5)
- 1-(2-Chloro-4-fluorophenyl)cyclopropanecarbonitrile (CAS 1260650-46-1)
Recommended Standards
- 4-Chloro-5-fluoro-2-methylquinoline (CAS 1799421-05-8)
- 2-Chloro-6-fluoro-4-methylquinoline (CAS 18529-12-9)
- 7-Chloro-6-fluoro-2-methylquinoline (CAS 165112-02-7)
- 2-(4-Chloro-3-fluorophenyl)pyrrole (CAS 1936405-09-2)
- [1,1'-Biphenyl]-4-carboximidamide hydrochloride (CAS 111082-23-6)
- 3-Boronoisonicotinic acid (CAS 1072946-05-4)
- Imidazo[1,2-a]pyrazin-3-ol (CAS 676460-49-4)
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