4-(2-Methyl-6-(trifluoromethyl)pyridin-3-yl)pyrimidine-2-thiol CAS 1858250-86-8

Description

The occurrence of 4-(2-Methyl-6-(trifluoromethyl)pyridin-3-yl)pyrimidine-2-thiol is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

4-(2-Methyl-6-(trifluoromethyl)pyridin-3-yl)pyrimidine-2-thiol (CAS 1858250-86-8) is a high-purity analytical reference standard with the molecular formula C11H8F3N3S and a molecular weight of 271.26 g/mol.

The molecular framework of 4-(2-Methyl-6-(trifluoromethyl)pyridin-3-yl)pyrimidine-2-thiol (C11H8F3N3S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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