2-Amino-5-chloro-3-fluorophenol CAS 186309-72-8
| CAS No. | 186309-72-8 |
| Molecular Formula | C6H5ClFNO |
| Molecular Weight | 161.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Amino-5-chloro-3-fluorophenol is closely related to an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-Amino-5-chloro-3-fluorophenol (CAS 186309-72-8) is a high-purity analytical reference standard with the molecular formula C6H5ClFNO and a molecular weight of 161.56 g/mol.
2-Amino-5-chloro-3-fluorophenol (C6H5ClFNO) contains an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Amino-5-chloro-3-fluorophenol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H5ClFNO |
| Molecular Weight | 161.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Amino Standards
- 4-Amino-2-chloro-3-fluorophenol (CAS 1003710-18-6)
- 2-Amino-5-chloro-4-fluorophenol (CAS 1191063-34-9)
- 3-Amino-4-chloro-2-fluorophenol (CAS 1427407-07-5)
- 3-Amino-2-chloro-4-fluorophenol (CAS 1427407-23-5)
- 2-Amino-4-chloro-5-fluorophenol (CAS 303181-72-8)
- 2-Amino-4-chloro-6-fluorophenol (CAS 862699-26-1)
- 2-Amino-6-chloro-4-fluorophenol (CAS 260253-17-6)
- 3-Amino-2-chloro-6-fluorophenol (CAS 2090777-63-0)
Recommended Standards
- 4-Chloro-5-fluoro-1-methylpyridin-2(1H)-one (CAS 1823887-04-2)
- (2-Chloro-5-fluoropyridin-3-yl)methanol (CAS 870063-52-8)
- (6-Chloro-4-fluoropyridin-2-yl)methanol (CAS 1807206-88-7)
- (5-Chloro-3-fluoropyridin-2-yl)methanol (CAS 214055-12-6)
- 5-Acetyl-2-{[3-(dimethylamino)propyl]amino}-6-methylpyridine-3-carbonitrile (CAS 306979-87-3)
- 1-(1-Bromoethyl)-3-fluorobenzene (CAS 405931-45-5)
- 6-Chloro-4-(chloromethyl)pyridin-2-amine (CAS 1393566-32-9)
- 2-Cyclopropyl-3-ethyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (CAS 1540372-00-6)
- (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoate (CAS 1369534-54-2)
- 3-(Trifluoromethoxy)benzohydrazide (CAS 321195-88-4)
- 4-(2-Fluorophenyl)-2-methoxyphenol (CAS 1261926-34-4)
- 2-((5-(4-Hydroxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-phenylacetamide (CAS 332906-58-8)
- 1-(2,4-Dichloro-5-methoxyphenyl)-N-(2,4-difluorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide (CAS 339099-48-8)
- Cycloaspeptide D (CAS 691363-62-9)
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