Bendamustine Impurity 9 CAS 1869075-90-0
| CAS No. | 1869075-90-0 |
| Molecular Formula | C22H33Cl2N3O7 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 558.88 g/mol gives Bendamustine Impurity 9 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Bendamustine Impurity 9 (CAS 1869075-90-0, C22H33Cl2N3O7HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Bendamustine Impurity 9 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 558.88 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Bendamustine Impurity 9 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H33Cl2N3O7 HCl |
| Molecular Weight | 558.88 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Bendamustine Standards
- Bendamustine impurity 33 (CAS 109882-25-9)
- Bendamustine Impurity 2 (CAS 109882-26-0)
- Bendamustine USP Related Compound E (CAS 109882-27-1)
- Bendamustine Dihydroxy Impurity (CAS 109882-29-3)
- Bendamustine USP Related Compound A (CAS 109882-30-6)
- Bendamustine-D8 Hydrochloride (CAS 1134803-33-0)
- Bendamustine Impurity 7 (CAS 1138238-08-0)
- Bendamustine Dideschloroethyl Acid Hydrochloride (CAS 1179363-38-2)
Recommended Standards
- Empagliflozin Impurity 278 (CAS CATO-C4X-1065278)
- Brivudine Impurity 10 (CAS 69304-48-9)
- Ornidazole Impurity 44 (CAS 13551-86-5)
- Ethyl 3-(methylsulfonyl)benzoate (CAS 83112-38-3)
- 4-(1,3-Thiazol-2-yl)-1,3-thiazol-2-amine (CAS 7520-81-2)
- [(2-chloro-6-fluorophenyl)methyl][3-(1h-imidazol-1-yl)propyl]amine (CAS 852934-12-4)
- N-Methyl-3-(1-methyl-1H-imidazol-2-yl)propan-1-amine dihydrochloride (CAS 1255717-78-2)
- 3-(Benzyloxy)isoxazole-5-carboxylic acid (CAS 2552-54-7)
- Cariprazine Impurity N2 (CAS 1231947-90-2)
- (Pro3)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt (CAS 299898-52-5)
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