Empagliflozin Impurity 278 CAS CATO-C4X-1065278
| CAS No. | CATO-C4X-1065278 |
| Molecular Formula | C23H29ClO8 |
| Molecular Weight | 468.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Empagliflozin Impurity 278 (CAS CATO-C4X-1065278), a pharmacopoeial impurity reference standard (molecular formula C23H29ClO8, MW 468.92 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Empagliflozin Impurity 278 (C23H29ClO8) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H29ClO8 |
| Molecular Weight | 468.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 110 (CAS CATO-C4X-1065110)
- Empagliflozin Impurity 12 (CAS 1620758-34-0 & 2452301-18-5)
- Empagliflozin Impurity 14 (CAS 1620758-34-0)
- Empagliflozin Impuirity 141 (CAS CATO-C4X-1065141)
- Empagliflozin Impurity 17 (CAS CATO-C4X-106517)
- Empagliflozin impurity 241 (CAS CATO-C4X-1065241)
- Empagliflozin Impurity 86 (CAS CATO-C4X-1065286)
- Empagliflozin Impurity 314 (CAS CATO-C4X-1065314)
Recommended Standards
- Dapagliflozin Impurity 84 (CAS CATO-C4X-113884)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com