Cabozantinib Impurity 19 CAS 18719-42-1
| CAS No. | 18719-42-1 |
| Molecular Formula | C9H15ClO4 |
| Molecular Weight | 222.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Cabozantinib Impurity 19 (CAS 18719-42-1), molecular formula C9H15ClO4 and molecular weight 222.67 g/mol, is a CATO reference standard with documented purity and traceability.
Cabozantinib Impurity 19 (C9H15ClO4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H15ClO4 |
| Molecular Weight | 222.67 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
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Recommended Standards
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- 4-Chloro-3-(methoxymethyl)quinolin-8-amine (CAS 190139-07-2)
- 4-Chloro-5-iodo-6-methylthieno[2,3-d]pyrimidine (CAS 1823374-38-4)
- 2-Cyclopropoxy-1-isopropyl-3-methoxybenzene (CAS 1243395-70-1)
- 3-(3-Bromophenyl)-5-(furan-2-ylmethylene)-4-thioxothiazolidin-2-one (CAS 306322-32-7)
- 4-(3-Thienyl)-2-pyrimidinamine (CAS 206564-03-6)
- 3-Bromo-6-chloroisoquinoline (CAS 1276056-79-1)
- Irbesartan Impurity 28 (CAS 194984-24-2)
- 1-Butyl-1H-benzimidazole (CAS 5465-30-5)
- Argatroban Impurity 16 (CAS CATO-C4X-100716)
- 2,7-Dibromo-9,10-phenanthrenequinone (CAS 84405-44-7)
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Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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