Cabozantinib Impurity 28 CAS 326-04-5
| CAS No. | 326-04-5 |
| Molecular Formula | C12H8F2N2O |
| Molecular Weight | 234.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Cabozantinib Impurity 28 (CAS 326-04-5, C12H8F2N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Cabozantinib Impurity 28 (C12H8F2N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 234.20 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Cabozantinib Impurity 28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8F2N2O |
| Molecular Weight | 234.20 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Cabozantinib Standards
- Cabozantinib Impurity 43 (CAS CATO-C4X-201843)
- Cabozantinib 4-Fluorocarbamoyl Methyl Ester Impurity (CAS 1345847-71-3)
- Cabozantinib Impurity 21 (CAS 849217-49-8)
- Cabozantinib Impurity 19 (CAS CATO-C4X-201819)
- Cabozantinib Impurity N2 (CAS 113136-79-1)
- Cabozantinib Impurity 4 (CAS CATO-C4X-20184)
- Cabozantinib Impurity 40 (CAS 1275738-77-6)
- Cabozantinib Impurity 4 (CAS 1247859-37-5)
Recommended Standards
- Sodium Cromoglicate Impurity 10 (CAS 50521-64-7)
- Phloroglucinol Dihydrate EP Impurity D (CAS 491-45-2)
- Riluzole Impurity 8 (CAS 1391054-04-8)
- Phloroglucinol Impurity 71 (CAS 112221-63-3)
- Palbociclib Impurity 24 2HCl (CAS 2458234-37-0（free base）)
- Mesalazine Impurity 51 (CAS CATO-C4X-132451)
- Nebivolol Impurity 63 (CAS CATO-C4X-196863)
- 2-Methyl-5-(p-methoxyphenyl)pyrimidine (CAS 82525-20-0)
- 5-Bromo-2-(thiophen-3-yl)-1H-indole-3-carbaldehyde (CAS 1323192-66-0)
- m-PEG5-CH2CH2COOH (CAS 1347750-72-4)
- 5-Ethyl-3-hydroxyindolin-2-one (CAS 1249072-63-6)
- 1-Iodo-2,5-dimethyl-3-nitrobenzene (CAS 52415-05-1)
- (1R)-1-(5,6,7,8-Tetrahydronaphthalen-2-yl)ethan-1-amine (CAS 1212104-62-5)
- Serpent Peptide 2AcOH (CAS 823202-99-9(free base))
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com