Almonertinib Impurity 1 CAS 1899922-04-3
| CAS No. | 1899922-04-3 |
| Molecular Formula | C29H33N7O2 |
| Molecular Weight | 511.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Almonertinib Impurity 1 (CAS 1899922-04-3) is a certified pharmaceutical impurity reference standard with the molecular formula C29H33N7O2 and a molecular weight of 511.62 g/mol.
The molecular framework of Almonertinib Impurity 1 (C29H33N7O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Almonertinib Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C29H33N7O2 |
| Molecular Weight | 511.62 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 7 |
Related Almonertinib Standards
Recommended Standards
- N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-((4-(4-methoxyphenyl)-5-(((4-methoxyphenyl)amino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 335402-09-0)
- Atrasentan Impurity 15 (CAS 1063836-09-8)
- DS1 (CAS 372497-52-4)
- Abemaciclib-d5 (CAS 1809251-51-1)
- Etrasimod Impurity 45 (CAS CATO-C4X-321445)
- Palbociclib Impurity 99 (CAS 2144748-14-9)
- Daptomycin Impurity 26 (CAS CATO-C4X-137826)
- 4-(tert-Butyl)-N-(4-(pyrrolidine-1-carbonyl)phenyl)benzenesulfonamide (CAS 727689-12-5)
- Biphenylene-2-carboxylic acid (CAS 93103-69-6)
- 2-(4-Chlorobenzyl)-5,6,7,8-tetrahydroquinazolin-4(1H)-one (CAS 87753-20-6)
- D-myo-Inositol-2,3-O-cyclohexylidene (CAS 57029-87-5)
- 2-(1-methyl-1H-pyrazol-4-yl)piperazine (CAS 1461713-45-0)
- Ac-Ala-Pro-Ala-pNA (CAS 61596-39-2)
- Semaglutide impurity 49 (CAS CATO-C4X-222649)
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