Danicopan (ACH-4471) CAS 1903768-17-1
| CAS No. | 1903768-17-1 |
| Molecular Formula | C26H23BrFN7O3 |
| Molecular Weight | 580.41 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Danicopan (ACH-4471) is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Danicopan (ACH-4471) (CAS 1903768-17-1), molecular formula C26H23BrFN7O3 and molecular weight 580.41 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Danicopan (ACH-4471) (C26H23BrFN7O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Danicopan (ACH-4471) under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C26H23BrFN7O3 |
| Molecular Weight | 580.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 7 |
Recommended Standards
- Lamotrigine Impurity 18 (CAS CATO-C4X-167218)
- 2,2'-(2,6-Bis(hexyloxy)naphthalene-1,5-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 2357137-42-7)
- 2,7-Dibromo-9,9-bis(3-(tert-butyl propanoate))fluorene (CAS 1030632-69-9)
- Alectinib Impurity 82 (CAS CATO-C4X-283682)
- 2-(4-Amino-3-methylphenoxy)acetonitrile (CAS 1016724-90-5)
- 2,4,6-Trimethyl-1,3,5-dithiazinane (CAS 638-17-5)
- (2-(2-Bromoethoxy)ethoxy)(tert-butyl)dimethylsilane (CAS 151556-43-3)
- (4R-cis)-6-Aminomethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester (CAS 853881-01-3)
- Tricosanoic Acid Methyl Ester (CAS 2433-97-8)
- 5-Ethynyl-1-methylpyrimidine-2,4(1H,3H)-dione (CAS 250658-12-9)
- (2Z)-3-(4-Chlorophenyl)-N-(4-fluorophenyl)prop-2-enamide (CAS 331461-49-5)
- Vancomycin EP Impurity E (CAS 55598-85-1)
- 3-Morpholinopicolinic acid (CAS 857283-75-1)
- Peptide Impurity 81 TFA (CAS CATO-CPTD788581)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com