2,5-Difluorophenylboronic Acid CAS 193353-34-3
| CAS No. | 193353-34-3 |
| Molecular Formula | C6H5BF2O2 |
| Molecular Weight | 157.91 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2,5-Difluorophenylboronic Acid (CAS 193353-34-3) is a high-purity analytical reference standard with the molecular formula C6H5BF2O2 and a molecular weight of 157.91 g/mol.
Structurally, 2,5-Difluorophenylboronic Acid (C6H5BF2O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.5, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 157.91 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5BF2O2 |
| Molecular Weight | 157.91 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2012 |
| Halogen Content | F-containing |
Related Difluorophenylboronic Standards
- 2,3-Difluorophenylboronic Acid (CAS 121219-16-7)
- 2,4-Difluorophenylboronic Acid (CAS 144025-03-6)
- 3,5-Difluorophenylboronic Acid (CAS 156545-07-2)
- 3,4-Difluorophenylboronic Acid (CAS 168267-41-2)
- 4-Acetyl-2,3-difluorophenylboronic acid (CAS 1451390-78-5)
- 3-Acetyl-2,6-difluorophenylboronic acid (CAS 1451390-81-0)
- 2,4-Difluorophenylboronic Acid Pinacol Ester (CAS 288101-48-4)
- 4-Acetyl-2,3-difluorophenylboronic acid pinacol ester (CAS 2121511-81-5)
Recommended Standards
- Gadolinium 158 (CAS 15068-71-0)
- (1-Methyl-4-piperidinyl)magnesium Chloride (0.5M THF)DISCONTINUED (CAS 63463-36-5)
- (2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)boronic acid (CAS 70523-22-7)
- (2,4-Dioxohexahydropyrimidin-5-yl)boronic acid (CAS 306935-91-1)
- 1-Chloronaphtho[2,1-b]thiophene-2-carbonitrile (CAS 886360-79-8)
- Boc-D-threo-3-(3-trifluoromethylphenyl)serine (CAS 1134411-38-3)
- Methyl 6-bromo-2H-chromene-3-carboxylate (CAS 177496-79-6)
- 5-Amino-3-(2-naphthyl)-1H-1,2,4-triazole (CAS 502686-00-2)
- Lusutrombopag Impurity 83 (CAS CATO-C4X-208483)
- 4-(Difluoromethoxy)-3-ethoxybenzaldehyde (CAS 162401-73-2)
- 1-[4-(aminomethyl)piperidin-1-yl]prop-2-en-1-one hydrochloride (CAS 1423027-66-0)
- 4,5-Dihydro Cefradine Impurity (CAS 37051-00-6)
- 2,2-Dimethyl-6-vinyl-4H-benzo[d][1,3]dioxine (CAS 860030-52-0)
- Acetyl Dipeptide-1 (CAS 196604-48-5)
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