Prednisolone impurity 58 CAS 19357-45-0
| CAS No. | 19357-45-0 |
| Molecular Formula | C23H32O5 |
| Molecular Weight | 388.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Prednisolone impurity 58 (CAS 19357-45-0, C23H32O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C23H32O5, Prednisolone impurity 58 contains a flavonoid core, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 388.50 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Prednisolone impurity 58 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H32O5 |
| Molecular Weight | 388.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
Related Prednisolone Standards
- Prednisolone Impurity 5 (CAS 2141-22-2)
- Prednisolone Acetate EP Impurity E (CAS 4380-55-6)
- Prednisolone Impurity 32 (CAS CATO-C4X-173732)
- Prednisolone Impurity 34 (CAS CATO-C4X-173734)
- 6α-Methyl Prednisolone-d3 (CAS CATO-C4X-173725)
- Prednisolone Impurity 28 (CAS 95440-71-4)
- Prednisolone Impurity 41 (CAS CATO-C4X-173741)
- Prednisolone impurity 60 (CAS CATO-C4X-173760)
Recommended Standards
- Hydrocortisone Impurity 64 (CAS 96391-56-9)
- Latanoprost Impurity 29 (CAS CATO-C4X-194129)
- Hydrocortisone EP Impurity K (CAS 640-87-9)
- Bimatoprost Acid (CAS 38344-08-0)
- Apremilast impurity 94 (CAS CATO-C4X-100994)
- Avatrombopag Impurity 118 (CAS CATO-C4X-2234118)
- Ampicillin Impurity 92 (CAS CATO-C4X-144392)
- 2-(Difluoromethyl)-6-fluoro-4-iodopyridine-3-acetic acid (CAS 1805053-82-0)
- 2-Chloro-N-(2-((2,5-dimethylphenyl)amino)-2-oxoethyl)-N-methylacetamide (CAS 757220-81-8)
- (E)-N-(4-Chlorophenyl)-N'-ethylpyridine-3-carboximidamide (CAS 338408-46-1)
- (S)-piperidin-3-ylmethanesulfonamide (CAS 2322935-82-8)
- 2-(Bromomethyl)-5-(difluoromethyl)-3-hydroxy-4-methylpyridine (CAS 1805548-39-3)
- 3-(3-chloro-4-ethoxyphenyl)cyclohex-2-en-1-one (CAS 1503512-09-1)
- Semaglutide impurity 32 (CAS CATO-C4X-222632)
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