Prednisolone Impurity 28 CAS 95440-71-4
| CAS No. | 95440-71-4 |
| Molecular Formula | C23H28O6 |
| Molecular Weight | 400.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Prednisolone Impurity 28 (CAS 95440-71-4, C23H28O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, Prednisolone Impurity 28 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 400.46 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Prednisolone Impurity 28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H28O6 |
| Molecular Weight | 400.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
Related Prednisolone Standards
- Prednisolone Impurity 41 (CAS CATO-C4X-173741)
- Prednisolone impurity 60 (CAS CATO-C4X-173760)
- Prednisolone Impurity 32 (CAS CATO-C4X-173732)
- Prednisolone Impurity 34 (CAS CATO-C4X-173734)
- Prednisolone Impurity 42 (CAS 3597-59-9)
- Prednisolone Acetate (CAS 52-21-1)
- Prednisolone 17-Acetate (CAS 52628-64-5)
- Prednisolone impurity 67 (CAS 20380-17-0)
Recommended Standards
- Prednisone Impurity 9 (CAS 2435-02-1)
- Bisphenol A Impurity 4 (CAS 19224-29-4)
- Eplerenone EP Impurity D (CAS 209253-82-7)
- Baricitinib Impurity 136 (CAS CATO-C4X-2260136)
- Topiramate Impurity 41 (CAS CATO-C4X-176841)
- Metoclopramide Impurity 22 (CAS CATO-C4X-141522)
- Axitinib Impurity 39 (CAS 31913-93-6)
- 8-(Trifluoromethyl)-2-azaspiro[4.5]decane (CAS 1341650-15-4)
- Tert-butyl (3-(piperazin-1-yl)bicyclo[1.1.1]Pentan-1-yl)carbamate (CAS 2227205-14-1)
- 2-(2-((4,5-Dichloro-1H-imidazol-1-yl)methyl)phenoxy)acetohydrazide (CAS 514803-20-4)
- cis-tert-Butyl hexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate (CAS 1257389-94-8)
- (S)-3-Amino-3-(3-bromophenyl)propanamide (CAS 1306136-92-4)
- Retinoic Acid Related Compound 22 (CAS 29444-27-7)
- Biotinyl-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt (CAS 1802086-28-7)
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